SCHEMBL3396102

SCHEMBL3396102

CNC(=O)c1c(-c2ccc(Oc3ccc(F)cc3)cc2)oc2cc(CC(C)O)c(C3CC3)cc12

nearest known ligand 0.49

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 8/20 0.49
CYP2C9 P11712 5/20 0.49
CYP2C19 P33261 4/20 0.49
KCNH2 Q12809 4/20 0.48
CYP2C8 P10632 4/20 0.38
ANO1 Q5XXA6 2/20 0.37
NR1I2 O75469 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3395916 0.83 CYP2C9 (0.65) CYP3A4CYP2C9CYP2C19KCNH2
SCHEMBL3396100 0.82 CYP3A4 (0.51) CYP3A4CYP2C9CYP2C19KCNH2CYP2C8
SCHEMBL3397837 0.82 CYP3A4 (0.47) CYP3A4CYP2C9CYP2C19KCNH2CYP2C8
SCHEMBL2845115 0.81 CYP3A4 (0.45) CYP3A4CYP2C9CYP2C19KCNH2CYP2C8
SCHEMBL2845478 0.81 CYP3A4 (0.43) CYP3A4CYP2C9CYP2C19KCNH2CYP2C8
SCHEMBL3395238 0.81 CYP2C9 (0.64) CYP3A4CYP2C9CYP2C19KCNH2
SCHEMBL2300601 0.80 CYP2C9 (0.54) CYP3A4CYP2C9CYP2C19KCNH2
SCHEMBL2838542 0.80 ANO1 (0.41) CYP3A4CYP2C9CYP2C19KCNH2CYP2C8
SCHEMBL3398826 0.80 CYP2C9 (0.54) CYP3A4CYP2C9CYP2C19KCNH2
SCHEMBL16509760 0.80 CYP2C9 (0.59) CYP3A4CYP2C9CYP2C19KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2245023-A1 HETEROCYCLIC ANTIVIRAL COMPOUNDS F. Hoffmann-La Roche AG (CH) 2010-11-03 EP disclosed
WO-2009101022-A1 HETEROCYCLIC ANTIVIRAL COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2009-08-20 WO disclosed