Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | HTT | P42858 | 3/20 | 0.72 |
| ▸ | HPGD | P15428 | 2/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.72 |
| ▸ | NPC1 | O15118 | 2/20 | 0.72 |
| ▸ | RAB9A | P51151 | 2/20 | 0.72 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | CDC7 | O00311 | 6/20 | 0.65 |
| ▸ | DBF4 | Q9UBU7 | 5/20 | 0.65 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.60 |
| ▸ | G6PD | P11413 | 1/20 | 0.59 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Buthiopurine SCHEMBL10380092 | 0.84 | PAK1 (0.66) | TSHRALDH1A1LMNAHTTHPGD | |
| SCHEMBL8696237 | 0.84 | TSHR (0.72) | TSHRALDH1A1LMNAHTTHPGD | |
| SCHEMBL10379467 | 0.82 | TSHR (0.69) | TSHRALDH1A1LMNAHTTHPGD | |
| SCHEMBL4253200 | 0.81 | TSHR (0.60) | TSHRALDH1A1LMNAHTTHPGD | |
| SCHEMBL9172563 | 0.80 | TSHR (0.67) | TSHRALDH1A1LMNAHTTHPGD | |
| SCHEMBL21456772 | 0.80 | TSHR (0.67) | TSHRALDH1A1LMNAHTTHPGD | |
| SCHEMBL9173815 | 0.80 | HIF1A (0.65) | TSHRALDH1A1LMNAHTTHPGD | |
| SCHEMBL29098331 | 0.80 | HIF1A (0.65) | TSHRALDH1A1LMNAHTTHPGD | |
| SCHEMBL2115555 | 0.78 | PAK1 (0.71) | TSHRALDH1A1LMNAHTTHPGD | |
| SCHEMBL31439407 | 0.78 | PAK1 (0.71) | TSHRALDH1A1LMNAHTTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111995626-B | 6- (acetyl-AA-mercapto) purine, its synthesis, activity and use | 首都医科大学 | 2023-06-27 | — | — | CN | claimed |
| CN-112110925-A | 6- (acetyl-AA-mercapto) purines, their synthesis, their activity in combination with cisplatin and their use | 首都医科大学 | 2020-12-22 | — | — | CN | claimed |
| CN-111995626-A | 6- (acetyl-AA-mercapto) purines, their synthesis, activity and use | 首都医科大学 | 2020-11-27 | — | — | CN | claimed |
| CN-112110925-B | 6- (acetyl-AA-mercapto) purine, its synthesis, activity and use in combination with cisplatin | 首都医科大学 | 2023-06-27 | — | — | CN | disclosed |
| CN-111995626-B | 6- (acetyl-AA-mercapto) purine, its synthesis, activity and use | 首都医科大学 | 2023-06-27 | — | — | CN | disclosed |
| CN-112110985-B | 6- (acetyl-Arg-Gly-Asp-AA-sulfhydryl) purine, synthesis, activity and application thereof | 首都医科大学 | 2022-09-02 | — | — | CN | disclosed |
| CN-112110986-B | 6-acetyl RGD mercaptopurine, synthesis thereof, activity of combination of 6-acetyl RGD mercaptopurine and cisplatin and application of 6-acetyl RGD mercaptopurine | 首都医科大学 | 2022-04-22 | — | — | CN | disclosed |
| CN-112110985-A | 6- (acetyl-Arg-Gly-Asp-AA-sulfhydryl) purine, synthesis, activity and application thereof | 首都医科大学 | 2020-12-22 | — | — | CN | disclosed |
| CN-112110986-A | 6-acetyl RGD mercaptopurine, synthesis thereof, activity of combination of 6-acetyl RGD mercaptopurine and cisplatin and application of 6-acetyl RGD mercaptopurine | 首都医科大学 | 2020-12-22 | — | — | CN | disclosed |
| CN-112110925-A | 6- (acetyl-AA-mercapto) purines, their synthesis, their activity in combination with cisplatin and their use | 首都医科大学 | 2020-12-22 | — | — | CN | disclosed |
| CN-111995626-A | 6- (acetyl-AA-mercapto) purines, their synthesis, activity and use | 首都医科大学 | 2020-11-27 | — | — | CN | disclosed |
| US-8653077-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2014-02-18 | — | — | US | disclosed |
| US-8637533-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2014-01-28 | — | — | US | disclosed |
| US-8492389-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2013-07-23 | — | — | US | disclosed |
| US-20120172591-A1 | INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2012-07-05 | — | — | US | disclosed |
| US-20120135994-A1 | INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2012-05-31 | — | — | US | disclosed |
| US-20100152211-A1 | INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION | 2010-06-17 | — | — | US | disclosed |
| WO-1990006312-A1 | 2',3'-DIDEOXYRIBOFURANOSIDES AND PROCESS FOR PRODUCING THEM | INSTITUT FÜR MOLEKULARBIOLOGIE UND ANALYTIK (IMA) GMBH (DE) | 1990-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152211-A1 | INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PIK3CG | TSHR 3873/4885ALDH1A1 4628/4885LMNA 3454/4885 |
| US-20120135994-A1 | INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PIK3CG | TSHR 3873/4885ALDH1A1 4628/4885LMNA 3454/4885 |
| US-20120172591-A1 | INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PIK3CG | TSHR 3873/4885ALDH1A1 4628/4885LMNA 3454/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.