Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | CDC7 | O00311 | 5/20 | 0.58 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.56 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10379467 | 0.86 | TSHR (0.69) | TSHRMAPTALDH1A1HPGDLMNA | |
| SCHEMBL3396404 | 0.84 | TSHR (0.78) | TSHRMAPTALDH1A1HPGDLMNA | |
| SCHEMBL6747965 | 0.83 | PAK1 (0.62) | TSHRMAPTALDH1A1HPGDLMNA | |
| SCHEMBL9254901 | 0.79 | HIF1A (0.61) | TSHRMAPTALDH1A1HPGDLMNA | |
| SCHEMBL9172563 | 0.77 | TSHR (0.67) | TSHRMAPTALDH1A1HPGDLMNA | |
| SCHEMBL21456772 | 0.77 | TSHR (0.67) | TSHRMAPTALDH1A1HPGDLMNA | |
| SCHEMBL31439407 | 0.76 | PAK1 (0.71) | TSHRMAPTALDH1A1HPGDLMNA | |
| SCHEMBL2115555 | 0.76 | PAK1 (0.71) | TSHRMAPTALDH1A1HPGDLMNA | |
| SCHEMBL6747197 | 0.76 | PAK1 (0.62) | TSHRMAPTALDH1A1HPGDLMNA | |
| SCHEMBL8701088 | 0.75 | KMT2A (0.43) | TSHRMAPTALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731320-A | TREATING PATIENT IN NEED OF IMMUNOSUPPRESSIVE, ANTIINFLAMMATORY OR ANTIPROLIFERATIVE THERAPY | ABBOTT LABORATORIES (US) | 1998-03-24 | — | — | US | disclosed |
| US-5672605-A | ADMINISTERING TO TREAT AUTOIMMUNE DISORDERS, TRANSPLANT REJECTION | ABBOTT LABORATORIES (US) | 1997-09-30 | — | — | US | disclosed |
| US-5643918-A | MACROCYCLIC COMPOUNDS TO REVERSE DRUG RESISTANCE, VIRICIDES, ANTIINFLAMMATORY AGENTS AND FUNGICIDES | ABBOTT LABORATORIES (US) | 1997-07-01 | — | — | US | disclosed |
| US-5583139-A | Marcolide immunomodulators | ABBOTT LABORATORIES (US) | 1996-12-10 | — | — | US | disclosed |
| US-5563172-A | MICROBIOCIDES, FUNGICIDES, VIRICIDES, ANTIINFLAMMATORY AGENTS, ANTIGROWTH AGENTS | ABBOTT LABORATORIES (US) | 1996-10-08 | — | — | US | disclosed |
| EP-0729471-A1 | SEMISYNTHETIC ANALOGS OF RAPAMYCIN (MACROLIDES) BEING IMMUNOMODULATORS | Abbott Laboratories (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5527907-A | IMMUNOSUPPRESSANTS | ABBOTT LABORATORIES (US) | 1996-06-18 | — | — | US | disclosed |
| WO-1995014023-A1 | SEMISYNTHETIC ANALOGS OF RAPAMYCIN (MACROLIDES) BEING IMMUNOMODULATORS | ABBOTT LABORATORIES (US) | 1995-05-26 | — | — | WO | disclosed |
| WO-1994021642-A1 | MACROCYCLIC AMIDE AND UREA IMMUNOMODULATORS | ABBOTT LABORATORIES (US) | 1994-09-29 | — | — | WO | disclosed |