Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.36 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395584 | 0.91 | MAP4K1 (0.45) | MAP4K1FGFR2ROCK2ROCK1SYK | |
| SCHEMBL3399624 | 0.88 | JAK3 (0.37) | MAP4K1EGFRJAK3JAK2SRC | |
| SCHEMBL3394239 | 0.87 | FLT3 (0.40) | MAP4K1EGFRJAK3JAK2MAP3K11 | |
| SCHEMBL3398973 | 0.87 | JAK3 (0.40) | MAP4K1EGFRJAK3JAK2PIM1 | |
| SCHEMBL3393665 | 0.86 | TTK (0.38) | MAP4K1JAK3JAK2SYKMAPK1 | |
| SCHEMBL3391851 | 0.86 | MAPK1 (0.37) | MAP4K1JAK3JAK2CYP2D6SYK | |
| SCHEMBL3397072 | 0.85 | JAK3 (0.36) | MAP4K1JAK3CYP2D6SYKMAPK1 | |
| SCHEMBL3395609 | 0.85 | PRKCA (0.41) | MAP4K1JAK3JAK2PIM1ROCK2 | |
| SCHEMBL3397048 | 0.84 | JAK3 (0.39) | MAP4K1JAK3JAK2AXLCYP2D6 | |
| SCHEMBL3394004 | 0.84 | JAK3 (0.38) | JAK3PIM1CYP2D6SYKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | claimed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | claimed |
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |