Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 6/20 | 0.36 |
| ▸ | HTR1A | P08908 | 5/20 | 0.36 |
| ▸ | HTR1B | P28222 | 5/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3419619 | 0.91 | KCNH2 (0.44) | KCNH2 | |
| SCHEMBL3425401 | 0.87 | KCNH2 (0.54) | KCNH2 | |
| SCHEMBL633466 | 0.86 | KCNH2 (0.41) | KCNH2KCNQ1CACNA1CHTR1DHTR1A | |
| SCHEMBL633467 | 0.86 | KCNH2 (0.41) | KCNH2KCNQ1CACNA1CHTR1DHTR1A | |
| SCHEMBL3423438 | 0.81 | KCNH2 (0.53) | KCNH2KCNQ1CACNA1CHTR1A | |
| SCHEMBL3428079 | 0.79 | KCNH2 (0.43) | KCNH2KCNQ1CACNA1C | |
| SCHEMBL633238 | 0.78 | KCNH2 (0.44) | KCNH2 | |
| SCHEMBL633720 | 0.78 | KCNH2 (0.44) | KCNH2 | |
| SCHEMBL3666412 | 0.76 | KCNH2 (0.40) | KCNH2 | |
| SCHEMBL589912 | 0.74 | KCNH2 (0.41) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245028-A1 | 5-AMINOCYCLYLMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-11-03 | — | — | EP | disclosed |
| EP-2244708-A1 | NEW 2,3,4,5-TEtRAHYDRO-1H-PYRIDO [4,3-B] INDOLE COMPOUNDS AND METHODS OF USE THEREOF | Medivation Technologies, Inc. (US) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009094668-A1 | NEW 2,3,4,5-TERAHYDRO-1H-PYRIDO[ 4,3-B] INDOLE COMPOUNDS AND METHODS OF USE THEREOF | MEDIVATION TECHNOLOGIES, INC. (US) | 2009-07-30 | — | — | WO | disclosed |
| WO-2009077989-A1 | 5-AMINOCYCLYLMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2009-06-25 | — | — | WO | disclosed |