Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.40 |
| ▸ | ADAM10 | O14672 | 3/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 3/20 | 0.39 |
| ▸ | KDM1A | O60341 | 10/20 | 0.37 |
| ▸ | MAOA | P21397 | 10/20 | 0.37 |
| ▸ | MAOB | P27338 | 10/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3423453 | 0.92 | PRCP (0.38) | PRCPADAM10ERBB2MMP2KDM1A | |
| SCHEMBL24481844 | 0.91 | PRCP (0.37) | PRCPADAM10ERBB2MMP2KDM1A | |
| SCHEMBL20528510 | 0.82 | KDM1A (0.40) | PRCPKDM1AMAOAMAOBMEN1 | |
| SCHEMBL3402260 | 0.82 | KDM1A (0.40) | PRCPKDM1AMAOAMAOBMEN1 | |
| SCHEMBL20011791 | 0.77 | ALDH1A1 (0.37) | — | |
| SCHEMBL18863654 | 0.76 | PRCP (0.40) | PRCPKDM1AMAOAMAOBMEN1 | |
| SCHEMBL18863653 | 0.76 | PRCP (0.40) | PRCPKDM1AMAOAMAOBMEN1 | |
| SCHEMBL3574526 | 0.76 | KDM1A (0.44) | PRCPKDM1AMAOAMAOBMEN1 | |
| SCHEMBL2328899 | 0.74 | RAD52 (0.38) | ADAM10ERBB2MMP2KDM1AMEN1 | |
| SCHEMBL24774588 | 0.74 | ADAM10 (0.33) | ADAM10ERBB2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247600-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Lead Therapeutics, Inc. (US) | 2010-11-10 | — | — | EP | claimed |
| WO-2009099736-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | WO | claimed |