Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | GPR3 | P46089 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA5A | P35218 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8540490 | 0.72 | TDP1 (0.30) | TDP1 | |
| SCHEMBL8458105 | 0.72 | GPR3 (0.50) | CA12CA9GPR3ALDH1A1ALOX15 | |
| SCHEMBL29700035 | 0.72 | GPR3 (0.50) | CA12CA9GPR3ALDH1A1ALOX15 | |
| SCHEMBL30515127 | 0.67 | GPR3 (0.68) | CA12CA9GPR3ALDH1A1ALOX15 | |
| SCHEMBL36332 | 0.67 | GPR3 (0.68) | CA12CA9GPR3ALDH1A1ALOX15 | |
| SCHEMBL10476774 | 0.67 | GPR3 (0.68) | CA12CA9GPR3ALDH1A1ALOX15 | |
| SCHEMBL4696033 | 0.67 | GPR3 (0.68) | CA12CA9GPR3ALDH1A1ALOX15 | |
| SCHEMBL9160474 | 0.67 | GPR3 (0.68) | CA12CA9GPR3ALDH1A1ALOX15 | |
| SCHEMBL29374932 | 0.67 | GPR3 (0.68) | CA12CA9GPR3ALDH1A1ALOX15 | |
| SCHEMBL11164867 | 0.67 | GPR3 (0.45) | CA12CA9GPR3ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4139362-A | SULFURIZATION, PEROXIDATION | THE ANSUL COMPANY (US) | 1979-02-13 | — | — | US | claimed |
| US-4084954-A | HERBICIDES, FUNGICIDES, NEMATOCIDES, INSECTICIDES | THE ANSUL COMPANY (US) | 1978-04-18 | — | — | US | claimed |
| US-20220024907-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2022-01-27 | — | — | US | disclosed |
| US-11174251-B2 | Compositions and methods for inhibition of the JAK pathway | RIGEL PHARMACEUTICALS, INC. (US) | 2021-11-16 | — | — | US | disclosed |
| EP-2598500-B1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS INC (US) | 2021-05-19 | — | — | EP | disclosed |
| US-20200216431-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2020-07-09 | — | — | US | disclosed |
| US-20200115371-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2020-04-16 | — | — | US | disclosed |
| US-10556891-B2 | Compositions and methods for inhibition of the JAK pathway | RIGEL PHARMACEUTICALS, INC. (US) | 2020-02-11 | — | — | US | disclosed |
| US-10479783-B2 | Compositions and methods for inhibition of the JAK pathway | RIGEL PHARMACEUTICALS, INC. (US) | 2019-11-19 | — | — | US | disclosed |
| US-RE47396-E1 | Compositions and methods for inhibition of the JAK pathway | RIGEL PHARMACEUTICALS, INC. (US) | 2019-05-21 | — | — | US | disclosed |
| US-20180265503-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2018-09-20 | — | — | US | disclosed |
| US-4177270-A | Soil fungicidal (nitrogen heterocyclic)-substituted-1,3-benzodithiole-2-ones | THE ANSUL COMPANY (US) | 1979-12-04 | — | — | US | disclosed |
| US-4177270-A | Soil fungicidal (nitrogen heterocyclic)-substituted-1,3-benzodithiole-2-ones | THE ANSUL COMPANY (US) | 1979-12-04 | — | — | US | disclosed |
| US-4175186-A | CYCLIZATION OF A NITROHALOBENZENE COMPOUND WITH A DIALKYDITHIOCARBAMIC ACID | THE ANSUL COMPANY (US) | 1979-11-20 | — | — | US | disclosed |
| US-4175186-A | CYCLIZATION OF A NITROHALOBENZENE COMPOUND WITH A DIALKYDITHIOCARBAMIC ACID | THE ANSUL COMPANY (US) | 1979-11-20 | — | — | US | disclosed |
| US-4175186-A | CYCLIZATION OF A NITROHALOBENZENE COMPOUND WITH A DIALKYDITHIOCARBAMIC ACID | THE ANSUL COMPANY (US) | 1979-11-20 | — | — | US | disclosed |
| US-4139362-A | SULFURIZATION, PEROXIDATION | THE ANSUL COMPANY (US) | 1979-02-13 | — | — | US | disclosed |
| US-4084954-A | HERBICIDES, FUNGICIDES, NEMATOCIDES, INSECTICIDES | THE ANSUL COMPANY (US) | 1978-04-18 | — | — | US | disclosed |
| US-4084954-A | HERBICIDES, FUNGICIDES, NEMATOCIDES, INSECTICIDES | THE ANSUL COMPANY (US) | 1978-04-18 | — | — | US | disclosed |
| US-4084954-A | HERBICIDES, FUNGICIDES, NEMATOCIDES, INSECTICIDES | THE ANSUL COMPANY (US) | 1978-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115371-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | JAK3, JAK2, JAK1 | CA12 4248/4885CA9 4469/4885GPR3 2697/4885 |
| US-20180265503-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | JAK3, JAK2, JAK1 | CA12 4262/4885CA9 4511/4885GPR3 2620/4885 |
| US-20200216431-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | JAK3, JAK2, JAK1 | CA12 4262/4885CA9 4511/4885GPR3 2620/4885 |
| US-11174251-B2 | Compositions and methods for inhibition of the JAK pathway | JAK3, JAK2, JAK1 | CA12 4248/4885CA9 4469/4885GPR3 2697/4885 |
| US-10479783-B2 | Compositions and methods for inhibition of the JAK pathway | JAK3, JAK2, JAK1 | CA12 4248/4885CA9 4469/4885GPR3 2697/4885 |
| US-10556891-B2 | Compositions and methods for inhibition of the JAK pathway | JAK3, JAK2, JAK1 | CA12 4262/4885CA9 4511/4885GPR3 2620/4885 |
| US-20220024907-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | JAK3, JAK2, JAK1 | CA12 4248/4885CA9 4469/4885GPR3 2697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.