SCHEMBL3396965

SCHEMBL3396965

Cc1cc(C#N)ccc1-c1cnnc(NCc2cc(-c3ccc(C(=O)O)o3)[nH]n2)n1

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
VNN1 O95497 3/20 0.33
KCNH2 Q12809 5/20 0.32
FASN P49327 1/20 0.32
IDH1 O75874 1/20 0.32
ATR Q13535 1/20 0.32
OXTR P30559 2/20 0.32
AVPR1A P37288 1/20 0.32
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
HPGD P15428 1/20 0.31
KMT2A Q03164 1/20 0.31
EIF4E P06730 1/20 0.31
SLC22A12 Q96S37 1/20 0.31
MAPT P10636 1/20 0.31
GSK3B P49841 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13425744 0.93 TSHR (0.35) VNN1KCNH2IDH1OXTRAVPR1A
SCHEMBL13425585 0.92 EGLN1 (0.35) VNN1KCNH2FASNIDH1ATR
SCHEMBL13425750 0.91 OXTR (0.34) VNN1KCNH2FASNIDH1ATR
SCHEMBL13426190 0.88 KCNH2 (0.36) KCNH2IDH1
SCHEMBL3397458 0.87 KCNH2 (0.34) KCNH2IDH1
SCHEMBL13426043 0.82 KCNH2 (0.43) KCNH2ALDH1A1GSK3B
SCHEMBL13425758 0.81 TNIK (0.43) KCNH2FASNOXTRAVPR1A
SCHEMBL13425784 0.80 KCNH2 (0.52) KCNH2IDH1ALDH1A1HPGDGSK3B
SCHEMBL13425783 0.80 KCNH2 (0.40) KCNH2FASNIDH1ALDH1A1
SCHEMBL3393484 0.79 ACP1 (0.39) VNN1KCNH2MEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010046780-A2 ANTI VIRAL COMPOUNDS INSTITUT PASTEUR KOREA (KR) 2010-04-29 WO disclosed
WO-2010046780-A2 ANTI VIRAL COMPOUNDS INSTITUT PASTEUR KOREA (KR) 2010-04-29 WO disclosed