Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401487 | 0.89 | HTR2C (0.55) | PPARDPPARAHTR2CRAB9AALDH1A1 | |
| SCHEMBL3403924 | 0.86 | HTR2C (0.47) | HTR2CRAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL3396857 | 0.84 | HTR2C (0.66) | HTR2CRAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL3401776 | 0.83 | HTR2C (0.45) | HTR2CRAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL3401169 | 0.83 | HTR2C (0.47) | HTR2CRAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL3398874 | 0.82 | PPARD (0.56) | PPARDPPARAALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL3404364 | 0.82 | HTR2C (0.51) | HTR2CRAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL3400911 | 0.81 | ALDH1A1 (0.47) | HTR2CRAB9AALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL3405112 | 0.81 | PPARD (0.54) | PPARDPPARAALDH1A1NPC1SMN1; SMN2 | |
| SCHEMBL3405368 | 0.79 | CRHR1 (0.41) | HTR2CRAB9AALDH1A1NPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |