Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1608336 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL21610975 | 0.73 | HSD17B10 (0.61) | SMN1; SMN2ALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL3400976 | 0.73 | KMT2A (0.50) | SMN1; SMN2ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL19012369 | 0.70 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL21336759 | 0.70 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL15652087 | 0.69 | HSD17B10 (0.59) | SMN1; SMN2ALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL18395136 | 0.69 | HSD17B10 (0.59) | SMN1; SMN2ALDH1A1NPSR1KMT2AMEN1 | |
| SCHEMBL8928897 | 0.69 | CYP3A4 (0.46) | SMN1; SMN2ALDH1A1NPSR1KMT2AHPGD | |
| SCHEMBL9526014 | 0.69 | PKM (0.46) | ALDH1A1NPSR1L3MBTL1KDM4EHPGD | |
| SCHEMBL26981190 | 0.69 | SMN1; SMN2 (0.58) | SMN1; SMN2ALDH1A1NPSR1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247588-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009107850-A2 | FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-09-03 | — | — | WO | disclosed |