Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.30 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380583 | 0.76 | F2 (0.42) | CHEK1PIM1PIM3PIM2SYK | |
| SCHEMBL3380579 | 0.59 | F10 (0.44) | PIM1PIM3PIM2SYKCDK2 | |
| SCHEMBL246730 | 0.58 | ALOX5AP (0.39) | — | |
| SCHEMBL3382319 | 0.56 | PDPK1 (0.39) | SYK | |
| SCHEMBL3391607 | 0.56 | TGFBR1 (0.46) | TGFBR1 | |
| SCHEMBL25011838 | 0.56 | ASIC3 (0.56) | PIM1AURKBCDK1MAPKAPK2TGFBR1 | |
| SCHEMBL30420906 | 0.56 | ASIC3 (0.56) | PIM1AURKBCDK1MAPKAPK2TGFBR1 | |
| SCHEMBL246654 | 0.56 | F10 (0.46) | PIM1SYKKDM5BMAPKAPK2TGFBR1 | |
| SCHEMBL12524273 | 0.55 | TGFBR1 (0.40) | PIM1PIM3PIM2TGFBR1 | |
| SCHEMBL13051144 | 0.55 | DYRK1A (0.60) | PIM1PIM3PIM2CDK2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012000595-A1 | 2,4- DIARYL - SUBSTITUTED [1,8] NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER | MERCK PATENT GMBH (DE) | 2012-01-05 | — | — | WO | disclosed |