Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.71 |
| ▸ | CA2 | P00918 | 1/20 | 0.71 |
| ▸ | CA9 | Q16790 | 1/20 | 0.71 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.33 |
| ▸ | LDHA | P00338 | 2/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.33 |
| ▸ | LDHB | P07195 | 1/20 | 0.33 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.33 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.33 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL2216673 | 1.00 | — | — | |
| Bicarbonate SCHEMBL27841404 | 0.94 | — | — | |
| Bicarbonate SCHEMBL10621132 | 0.94 | — | — | |
| Bicarbonate SCHEMBL4735636 | 0.94 | — | — | |
| Bicarbonate SCHEMBL2359529 | 0.94 | — | — | |
| Bicarbonate SCHEMBL28033152 | 0.94 | — | — | |
| Bicarbonate SCHEMBL2987016 | 0.94 | CA1 (0.62) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL10581921 | 0.94 | CA1 (0.62) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL8531740 | 0.93 | CA1 (0.83) | CA1CA2CA9FFAR3ACHE | |
| Bicarbonate SCHEMBL5458673 | 0.93 | CA1 (0.83) | CA1CA2CA9FFAR3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247596-A2 | NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI -CANCER AGENTS | Natco Pharma Limited (IN) | 2010-11-10 | — | — | EP | claimed |
| WO-2009098715-A2 | NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI -CANCER AGENTS | NATCO PHARMA LIMITED (IN) | 2009-08-13 | — | — | WO | claimed |
| CN-119301305-A | Circuit board copper chloride etching waste liquid precipitation treatment recycling method and device | 叶涛 | 2025-01-10 | — | — | CN | disclosed |
| CN-108128804-B | The industrial carbonic acid zirconium and preparation method thereof of the good stable storing of purity high activity | GUANGTONG CHEMICAL CO., LTD., ZIBO (CN) | 2019-11-01 | — | — | CN | disclosed |
| US-8845759-B2 | Reduction of ammonia smell in substances for oxidative dyeing and/or lightening keratin fibres | HENKEL AG & CO. KGAA (DE) | 2014-09-30 | — | — | US | disclosed |
| US-20140165299-A1 | REDUCTION OF AMMONIA SMELL IN SUBSTANCES FOR OXIDATIVE DYEING AND/OR LIGHTENING KERATIN FIBRES | HENKEL AG & CO. KGAA (DE) | 2014-06-19 | — | — | US | disclosed |
| US-8349847-B2 | Pyrazolo [3,4-D] pyrimidine derivatives as anti-cancer agents | KONAKANCHI DURGA PRASAD (IN) | 2013-01-08 | — | — | US | disclosed |
| US-20100298351-A1 | NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS | NATCO PHARMA LIMITED (IN) | 2010-11-25 | — | — | US | disclosed |
| EP-2247596-A2 | NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI -CANCER AGENTS | Natco Pharma Limited (IN) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009098715-A2 | NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI -CANCER AGENTS | NATCO PHARMA LIMITED (IN) | 2009-08-13 | — | — | WO | disclosed |
| US-20040033435-A1 | Underlayer of a water-insoluble and alkali-soluble resin; image-recording layer of the resin plus an infrared absorbent; for making a multilayer infrared laser positive-working printing plate | FUJI PHOTO FILM CO., LTD. | 2004-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140165299-A1 | REDUCTION OF AMMONIA SMELL IN SUBSTANCES FOR OXIDATIVE DYEING AND/OR LIGHTENING KERATIN FIBRES | KRT18, OAT, AKR7A2 | CA1 2831/4885CA2 1668/4885CA9 1994/4885 |
| US-20100298351-A1 | NOVEL PYRAZOLO [3, 4 -D] PYRIMIDINE DERIVATIVES AS ANTI-CANCER AGENTS | DPYD, TYMP, TYMS | CA1 3985/4885CA2 3477/4885CA9 2881/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.