Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL1586108 | 0.94 | — | — | |
| Bicarbonate SCHEMBL4527463 | 0.94 | — | — | |
| Bicarbonate SCHEMBL28859610 | 0.94 | — | — | |
| Bicarbonate SCHEMBL3265752 | 0.94 | — | — | |
| Bicarbonate SCHEMBL3265746 | 0.94 | — | — | |
| Bicarbonate SCHEMBL29597616 | 0.94 | — | — | |
| Bicarbonate SCHEMBL2216673 | 0.94 | — | — | |
| Bicarbonate SCHEMBL4527467 | 0.94 | — | — | |
| Bicarbonate SCHEMBL3397277 | 0.94 | CA1 (0.71) | — | |
| Bicarbonate SCHEMBL14829871 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3313866-B1 | COMPOSITIONS AND METHODS FOR TREATING CANCER AND PROMOTING WOUND HEALING | UNIV LOUISVILLE RES FOUND INC (US) | 2024-11-20 | — | — | EP | disclosed |
| US-11524062-B2 | Compositions and methods for treating cancer and promoting wound healing | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2022-12-13 | — | — | US | disclosed |
| US-20210038708-A1 | Compositions And Methods For Treating Cancer And Promoting Wound Healing | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. | 2021-02-11 | — | — | US | disclosed |
| US-10758605-B2 | Compositions and methods for treating cancer and promoting wound healing | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2020-09-01 | — | — | US | disclosed |
| US-20190111123-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER AND PROMOTING WOUND HEALING | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2019-04-18 | — | — | US | disclosed |
| EP-3313866-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER AND PROMOTING WOUND HEALING | University Of Louisville Research Foundation, Inc. (US) | 2018-05-02 | — | — | EP | disclosed |
| WO-2017004168-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER AND PROMOTING WOUND HEALING | UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. (US) | 2017-01-05 | — | — | WO | disclosed |
| WO-2008060449-A2 | MICROFLUIDIC DETECTOR | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2008-05-22 | — | — | WO | disclosed |
| US-20060104950-A1 | Methods of Tranducing genes into T cells | DNAVEC RESEARCH INC. (JP) | 2006-05-18 | — | — | US | disclosed |
| EP-1561819-A1 | METHOD OF TRANSFERRING GENE INTO T CELLS | Dnavec Research Inc. (JP) | 2005-08-10 | — | — | EP | disclosed |
| US-20030165475-A1 | Non-lethal methods for conditioning a recipient for bone marrow transplantation | ILDSTAD SUZANNE T (US) | 2003-09-04 | — | — | US | disclosed |
| US-20010009663-A1 | Given dose of radiation, followed by transplantation with a donor cell containing hematopoietic stem cells not compatible with the recipient's major histocompatibility complex; prevents graft-versus-host disease | ILDSTAD SUZANNE T (US) | 2001-07-26 | — | — | US | disclosed |
| US-6217867-B1 | ADMINISTERING RADIATION; MONOCLONAL ANTIBODIES | UNIVERSITY OF PITTSBURGH | 2001-04-17 | — | — | US | disclosed |
| US-5876692-A | TO PREVENT HOST REJECTION RESPONSES. | THE UNIVERSITY OF PITTSBURGH (US) | 1999-03-02 | — | — | US | disclosed |
| US-5635156-A | SUBJECTING RECIPIENT TO TREATMENT WITH NON-LETHAL DOSE OF TOTAL BODY IRRADIATION, ALKYLATING AGENT, ANTIBODY OR ACTIVE FRAGMENT THEREOF, TRANSPLANTING WITH DONOR CELL PREPARATION CONTAINING HEMATOPOIETIC STEM CELLS | UNIVERSITY OF PITTSBURGH (US) | 1997-06-03 | — | — | US | disclosed |
| US-5514364-A | Non-lethal methods for conditioning a recipient for bone marrow transplantation | UNIVERSITY OF PITTSBURGH (US) | 1996-05-07 | — | — | US | disclosed |
| US-4340253-A | Preflush-lixiviant process for solution mining of uranium ore beds | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE INTERIOR (US) | 1982-07-20 | — | — | US | disclosed |