Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL67753 | 1.00 | ALDH1A1 (0.44) | ALDH1A1KMT2AMEN1L3MBTL1KDM4E | |
| SCHEMBL3425272 | 1.00 | ALDH1A1 (0.44) | ALDH1A1KMT2AMEN1L3MBTL1KDM4E | |
| SCHEMBL2686951 | 0.90 | GNAI3 (0.41) | ALDH1A1KMT2AMEN1L3MBTL1KDM4E | |
| SCHEMBL3425809 | 0.90 | GNAI3 (0.41) | ALDH1A1KMT2AMEN1L3MBTL1KDM4E | |
| SCHEMBL3428769 | 0.82 | ALDH1A1 (0.43) | ALDH1A1KMT2AMEN1LMNAPOLB | |
| SCHEMBL3398142 | 0.82 | ALDH1A1 (0.38) | ALDH1A1KMT2APAX8MAPT | |
| SCHEMBL13010 | 0.81 | ALDH1A1 (0.65) | ALDH1A1KMT2AMEN1L3MBTL1KDM4E | |
| SCHEMBL12922 | 0.81 | ALDH1A1 (0.65) | ALDH1A1KMT2AMEN1L3MBTL1KDM4E | |
| SCHEMBL20698377 | 0.81 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1L3MBTL1KDM4E | |
| SCHEMBL20698378 | 0.81 | ALDH1A1 (0.46) | ALDH1A1KMT2AMEN1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | claimed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | claimed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | claimed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |