Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 9/20 | 0.65 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.65 |
| ▸ | BCHE | P06276 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | ACACB | O00763 | 1/20 | 0.52 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5105167 | 0.87 | S1PR1 (0.60) | MTNR1AMTNR1BBCHEKDM4EL3MBTL1 | |
| SCHEMBL3396113 | 0.87 | CYP2D6 (0.56) | MTNR1AMTNR1BKDM4EMAPK1 | |
| SCHEMBL3398988 | 0.87 | CYP2D6 (0.55) | MTNR1AMTNR1BKDM4EMAPK1L3MBTL1 | |
| SCHEMBL5105375 | 0.85 | BCHE (0.65) | BCHEL3MBTL1 | |
| SCHEMBL5092357 | 0.81 | S1PR1 (0.62) | MTNR1AMTNR1BBCHEKDM4EL3MBTL1 | |
| SCHEMBL3400228 | 0.80 | MTNR1A (0.68) | MTNR1AMTNR1BKDM4E | |
| SCHEMBL14197926 | 0.79 | BCHE (0.67) | BCHEKDM4EMAPK1 | |
| SCHEMBL30821653 | 0.79 | BCHE (0.67) | BCHEKDM4EMAPK1 | |
| SCHEMBL21634272 | 0.79 | BCHE (0.67) | BCHEKDM4EMAPK1 | |
| SCHEMBL3397413 | 0.79 | MTNR1A (1.00) | MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8791163-B2 | Melatonin ligands having antidepressant activity as well as sleep inducing properties | MCGILL UNIVERSITY (CA) | 2014-07-29 | — | — | US | disclosed |
| US-20100267836-A1 | NOVEL MELATONIN LIGANDS HAVING ANTIDEPRESSANT ACTIVITY AS WELL AS SLEEP INDUCING PROPERTIES | UNIVERSITA DEGLI STUDI DI MILANO (IT) | 2010-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267836-A1 | NOVEL MELATONIN LIGANDS HAVING ANTIDEPRESSANT ACTIVITY AS WELL AS SLEEP INDUCING PROPERTIES | HCRTR1, HCRTR2, MTNR1A | MTNR1A 3/4885MTNR1B 5/4885BCHE 1695/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.