Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 16/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3422782 | 0.99 | ACHE (0.71) | ACHEMAPTGAAPKMHTT | |
| Hydrochloric Acid SCHEMBL3396105 | 0.97 | ACHE (0.69) | ACHEMAPTGAAPKMHTT | |
| Acetic Acid SCHEMBL3393948 | 0.91 | ACHE (0.61) | ACHEMEN1KMT2A | |
| Bromide SCHEMBL3398696 | 0.87 | ACHE (0.59) | ACHEMEN1KMT2A | |
| SCHEMBL3427055 | 0.86 | ACHE (0.61) | ACHEMEN1KMT2A | |
| SCHEMBL3424200 | 0.84 | ACHE (0.56) | ACHEMAPTGAAPKMHTT | |
| Hydrochloric Acid SCHEMBL3424903 | 0.84 | ACHE (0.59) | ACHEHTTMEN1KMT2A | |
| SCHEMBL3394724 | 0.84 | ACHE (0.53) | ACHEPKM | |
| SCHEMBL3434723 | 0.83 | ACHE (0.50) | ACHEMAPTGAAPKMHTT | |
| SCHEMBL3424278 | 0.82 | ACHE (1.00) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245013-A1 | 9-Ý4-(AMINO) PHENYL¨ACRIDINIUM SALTS AS CATIONIC DIRECT DYES FOR COLORING KERATINOUS FIBERS | Henkel AG & Co. KGaA (DE) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009103798-A1 | 9-[4-(AMINO) PHENYL] ACRIDINIUM SALTS AS CATIONIC DIRECT DYES FOR COLORING KERATINOUS FIBERS | HENKEL AG & CO. KGAA (DE) | 2009-08-27 | — | — | WO | disclosed |