Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 16/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3427055 | 0.99 | ACHE (0.61) | ACHEL3MBTL1MEN1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL3424903 | 0.97 | ACHE (0.59) | ACHEL3MBTL1MEN1NPC1RAB9A | |
| Bromide SCHEMBL3397501 | 0.87 | ACHE (0.69) | ACHEMEN1KMT2A | |
| SCHEMBL3422782 | 0.86 | ACHE (0.71) | ACHEMEN1KMT2A | |
| SCHEMBL3427784 | 0.85 | ACHE (0.48) | ACHEL3MBTL1MEN1NPC1RAB9A | |
| SCHEMBL3427123 | 0.85 | ACHE (0.45) | ACHEL3MBTL1MEN1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL3396105 | 0.84 | ACHE (0.69) | ACHE | |
| SCHEMBL3398018 | 0.84 | ACHE (0.48) | ACHEL3MBTL1MEN1KMT2A | |
| Bromide SCHEMBL3396190 | 0.82 | ACHE (0.40) | ACHEL3MBTL1MEN1NPC1RAB9A | |
| SCHEMBL3425204 | 0.81 | ACHE (0.41) | ACHEL3MBTL1MEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245013-A1 | 9-Ý4-(AMINO) PHENYL¨ACRIDINIUM SALTS AS CATIONIC DIRECT DYES FOR COLORING KERATINOUS FIBERS | Henkel AG & Co. KGaA (DE) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009103798-A1 | 9-[4-(AMINO) PHENYL] ACRIDINIUM SALTS AS CATIONIC DIRECT DYES FOR COLORING KERATINOUS FIBERS | HENKEL AG & CO. KGAA (DE) | 2009-08-27 | — | — | WO | disclosed |