Demannose

Demannose

SCHEMBL3397670

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nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Demannose. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
TDP1 Q9NUW8 1/20 0.46
MPI P34949 1/20 0.44
PDE4A P27815 1/20 0.40
USP2 O75604 1/20 0.38
SLCO1B1 Q9Y6L6 1/20 0.38
AKR1B1 P15121 1/20 0.37
KDM4E B2RXH2 2/20 0.35
CYP2C19 P33261 1/20 0.30
HIF1A Q16665 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Demannose SCHEMBL30973585 1.00 LMNA (0.48) LMNAL3MBTL1TDP1MPIPDE4A
Demannose SCHEMBL361547 1.00 LMNA (0.48) LMNAL3MBTL1TDP1MPIPDE4A
Demannose SCHEMBL31755099 1.00 LMNA (0.48) LMNAL3MBTL1TDP1MPIPDE4A
Demannose SCHEMBL23721809 1.00 LMNA (0.48) LMNAL3MBTL1TDP1MPIPDE4A
Demannose SCHEMBL285569 1.00 LMNA (0.48) LMNAL3MBTL1TDP1MPIPDE4A
Demannose SCHEMBL25380809 1.00 LMNA (0.48) LMNAL3MBTL1TDP1MPIPDE4A
Demannose SCHEMBL6533561 1.00 LMNA (0.48) LMNAL3MBTL1TDP1MPIPDE4A
Demannose SCHEMBL25381696 1.00 LMNA (0.48) LMNAL3MBTL1TDP1MPIPDE4A
Galactose SCHEMBL361095 1.00 LMNA (0.48) LMNAL3MBTL1TDP1MPIPDE4A
Demannose SCHEMBL30572907 1.00 LMNA (0.48) LMNAL3MBTL1TDP1MPIPDE4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2244553-A2 GENETICALLY MODIFIED PHOTOAUTOTROPHIC ETHANOL PRODUCING HOST CELLS, METHOD FOR PRODUCING THE HOST CELLS, CONSTRUCTS FOR THE TRANSFORMATION OF THE HOST CELLS, METHOD FOR TESTING A PHOTOAUTOTROPHIC STRAIN FOR A DESIRED GROWTH PROPERTY AND METHOD OF PRODUCING ETHANOL USING THE HOST CELLS Algenol Biofuels Inc. (US) 2010-11-03 EP disclosed
WO-2009098089-A2 GENETICALLY MODIFIED PHOTOAUTOTROPHIC ETHANOL PRODUCING HOST CELLS, METHOD FOR PRODUCING THE HOST CELLS, CONSTRUCTS FOR THE TRANSFORMATION OF THE HOST CELLS, METHOD FOR TESTING A PHOTOAUTOTROPHIC STRAIN FOR A DESIRED GROWTH PROPERTY AND METHOD OF PRODUCING ETHANOL USING THE HOST CELLS BAIER KERSTIN (DE) 2009-08-13 WO disclosed