Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.48 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.48 |
| ▸ | PDE2A | O00408 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405826 | 0.99 | DPP4 (0.49) | ALDH1A1DPP4DPP8CHRM4PDE2A | |
| SCHEMBL3404779 | 0.94 | MAPK1 (0.49) | ALDH1A1CHRM4DRD2GAANPSR1 | |
| SCHEMBL3402107 | 0.93 | DRD2 (0.47) | ALDH1A1CHRM4DRD2GAANPSR1 | |
| SCHEMBL3401355 | 0.92 | DPP4 (0.54) | ALDH1A1DPP4DPP8CHRM4PDE2A | |
| SCHEMBL3400943 | 0.91 | DPP4 (0.56) | ALDH1A1DPP4DPP8CHRM4CNR1 | |
| SCHEMBL3402323 | 0.88 | DPP4 (0.49) | ALDH1A1DPP4DPP8CHRM4DRD2 | |
| SCHEMBL3402762 | 0.88 | NPC1 (0.53) | ALDH1A1CHRM4PDE2APDE10ANPSR1 | |
| SCHEMBL3405324 | 0.88 | CHRM4 (0.51) | ALDH1A1CHRM4PDE2APDE10AGAA | |
| SCHEMBL3402094 | 0.87 | DPP4 (0.50) | ALDH1A1DPP4DPP8CHRM4DRD2 | |
| SCHEMBL3403391 | 0.87 | CHRM4 (0.50) | ALDH1A1CHRM4PDE2APDE10AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |