Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 2/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.49 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405324 | 0.99 | CHRM4 (0.51) | CHRM4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3401105 | 0.94 | CHRM4 (0.49) | CHRM4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3405412 | 0.93 | CHRM4 (0.49) | CHRM4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3405826 | 0.88 | DPP4 (0.49) | CHRM4EPHX2ALDH1A1GAAHSD17B10 | |
| SCHEMBL3398247 | 0.87 | ALDH1A1 (0.48) | CHRM4EPHX2ALDH1A1GAAPDE2A | |
| SCHEMBL3400988 | 0.84 | CHRM4 (0.53) | CHRM4ALDH1A1NPC1GAAPPARD | |
| SCHEMBL3401416 | 0.84 | NPC1 (0.53) | CHRM4ALDH1A1NPC1PPARDHSD17B10 | |
| SCHEMBL3403462 | 0.84 | CHRM4 (0.65) | CHRM4CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL3405620 | 0.83 | CHRM4 (0.47) | CHRM4NPC1 | |
| SCHEMBL3402762 | 0.83 | NPC1 (0.53) | CHRM4ALDH1A1NPC1PPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |