Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.54 |
| ▸ | CTSB | P07858 | 1/20 | 0.54 |
| ▸ | CTSK | P43235 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 5/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.45 |
| ▸ | TLR4 | O00206 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | CPB1 | P15086 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28209924 | 0.87 | ALDH1A1 (0.49) | CTSLCTSBCTSKALDH1A1GAA | |
| SCHEMBL20495191 | 0.85 | HDAC11 (0.47) | HDAC11 | |
| SCHEMBL29083371 | 0.84 | ALDH1A1 (0.53) | CTSLCTSBCTSKALDH1A1GAA | |
| SCHEMBL21802063 | 0.84 | ALDH1A1 (0.53) | CTSLCTSBCTSKALDH1A1GAA | |
| SCHEMBL15265196 | 0.84 | ALDH1A1 (0.53) | CTSLCTSBCTSKALDH1A1GAA | |
| SCHEMBL376598 | 0.84 | ALDH1A1 (0.53) | CTSLCTSBCTSKALDH1A1GAA | |
| SCHEMBL21166309 | 0.84 | KMT2A (0.59) | CTSLCTSBCTSKHDAC11 | |
| SCHEMBL146868 | 0.83 | ALDH1A1 (0.52) | CTSLCTSBCTSKALDH1A1GAA | |
| SCHEMBL15595187 | 0.83 | OGA (0.46) | ALDH1A1HDAC11 | |
| SCHEMBL18922700 | 0.83 | OGA (0.46) | ALDH1A1HDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250171-A2 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | Achaogen, Inc. (US) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009137130-A2 | ANTIBACTERIAL FLUOROQUINOLONE ANALOGS | ACHAOGEN, INC. (US) | 2009-11-12 | — | — | WO | disclosed |