Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401069 | 0.94 | MAPK1 (0.48) | GAASMN1; SMN2KDM4EALDH1A1TP53 | |
| SCHEMBL3405341 | 0.92 | KDM4E (0.51) | GAASMN1; SMN2KDM4EALDH1A1TP53 | |
| SCHEMBL14545475 | 0.90 | KDM4E (0.46) | GAASMN1; SMN2KDM4EALDH1A1TP53 | |
| SCHEMBL3400291 | 0.87 | GAA (0.45) | GAASMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL3399977 | 0.84 | TSHR (0.53) | GAASMN1; SMN2KDM4EALDH1A1TP53 | |
| SCHEMBL3403957 | 0.83 | PANK3 (0.46) | GAASMN1; SMN2KDM4EALDH1A1TP53 | |
| SCHEMBL3405318 | 0.82 | HTR2C (0.47) | GAASMN1; SMN2KDM4EALDH1A1POLB | |
| SCHEMBL3398247 | 0.80 | ALDH1A1 (0.48) | GAASMN1; SMN2ALDH1A1PDE2ANPSR1 | |
| SCHEMBL3405826 | 0.79 | DPP4 (0.49) | GAAALDH1A1PDE2AHSD17B10NPSR1 | |
| SCHEMBL3399671 | 0.78 | MAPT (0.47) | GAASMN1; SMN2KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |