Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 7/20 | 0.53 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7644288 | 0.84 | TLR8 (0.55) | KMT2AHTR2CHTR2ATLR8 | |
| SCHEMBL8926575 | 0.81 | HTR2C (0.42) | KMT2AHTR2CHTR2AKDM4ENISCH | |
| SCHEMBL5486071 | 0.79 | HTR2C (0.66) | KMT2AHTR2CHTR2AKDM4ENISCH | |
| SCHEMBL28781053 | 0.78 | KMT2A (0.48) | KMT2AHTR2CHTR2ANISCHCYP2A6 | |
| SCHEMBL14368636 | 0.77 | HTR2C (0.41) | KMT2AHTR2CHTR2ADYRK1A | |
| Hydrochloric Acid SCHEMBL7177034 | 0.75 | KMT2A (0.43) | KMT2AHTR2CKDM4EMC4RNISCH | |
| Hydrochloric Acid SCHEMBL7176630 | 0.75 | KMT2A (0.43) | KMT2AHTR2CKDM4EMC4RNISCH | |
| Hydrochloric Acid SCHEMBL7177916 | 0.75 | KMT2A (0.43) | KMT2AHTR2CKDM4EMC4RNISCH | |
| Hydrochloric Acid SCHEMBL7180472 | 0.75 | KMT2A (0.43) | KMT2AHTR2CKDM4EMC4RNISCH | |
| Hydrochloric Acid SCHEMBL7171336 | 0.75 | KMT2A (0.43) | KMT2AHTR2CKDM4EMC4RNISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100297035-A1 | Thiazole Amides, Imidazole Amides and Related Analogues | LIGAND PHARMACEUTICALS, INC. (US) | 2010-11-25 | — | — | US | disclosed |
| US-20100297035-A1 | Thiazole Amides, Imidazole Amides and Related Analogues | LIGAND PHARMACEUTICALS, INC. (US) | 2010-11-25 | — | — | US | disclosed |
| US-20100297035-A1 | Thiazole Amides, Imidazole Amides and Related Analogues | LIGAND PHARMACEUTICALS, INC. (US) | 2010-11-25 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| EP-1848428-A2 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORPORATION (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |
| WO-2006089076-A2 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORPORATION (US) | 2006-08-24 | — | — | WO | disclosed |
| US-4259439-A | DIMETHINECYANINE DYE SENSITIZER | MITSUBISHI PAPER MILLS, LTD. (JP) | 1981-03-31 | — | — | US | disclosed |
| US-4147554-A | 5,6-DIHYDRO-PYRROLO(2,1-A)ISOQUINOLINES | MITSUBISHI PAPER MILLS, LTD. (JP) | 1979-04-03 | — | — | US | disclosed |
| US-4134769-A | BETAINE AND ANIONIC TYPE CYANINE DYES | MITSUBISHI PAPER MILLS, LTD. (JP) | 1979-01-16 | — | — | US | disclosed |
| US-4053318-A | SENSITIZING MEROCYANINE DYE | FUJI PHOTO FILM CO., LTD. (JA) | 1977-10-11 | — | — | US | disclosed |
| US-3966477-A | Spectrally sensitized silver halide photographic emulsion | FUJI PHOTO FILM CO., LTD. (JA) | 1976-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100297035-A1 | Thiazole Amides, Imidazole Amides and Related Analogues | HRH3, HRH4, HRH2 | KMT2A 890/4885HTR2C 416/4885HTR2A 323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.