Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 10/20 | 0.42 |
| ▸ | BRAF | P15056 | 3/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL676066 | 0.81 | ALK (0.53) | ALKBRAFACHEMAOA | |
| SCHEMBL675823 | 0.78 | ALK (0.51) | ALKACHEHRH3UTS2R | |
| SCHEMBL3668987 | 0.71 | ALK (0.61) | ALK | |
| SCHEMBL675708 | 0.69 | ALK (0.68) | ALK | |
| SCHEMBL3727917 | 0.68 | MAOA (0.44) | ALKMAOAHRH3UTS2R | |
| SCHEMBL676245 | 0.66 | ALK (0.62) | ALK | |
| SCHEMBL3722596 | 0.65 | HRH3 (0.40) | ALKACHEHRH3UTS2R | |
| SCHEMBL675901 | 0.65 | ALK (0.50) | ALKMAOA | |
| SCHEMBL675900 | 0.65 | ALK (0.50) | ALKMAOA | |
| SCHEMBL3399377 | 0.65 | LSS (0.47) | ACHEMAOAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010025872-A2 | ALFA-CARBOLINE INHIBITORS OF NPM-ALK, RET, AND BCR-ABL | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2010-03-11 | — | — | WO | disclosed |