Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | POLR1A | O95602 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13310019 | 0.87 | SRC (0.47) | POLBSMN1; SMN2ALDH1A1PARP1 | |
| SCHEMBL3402676 | 0.85 | PARP1 (0.46) | KMT2APOLBALDH1A1PARP1 | |
| SCHEMBL3402635 | 0.84 | MEN1 (0.47) | KMT2APOLBPARP1 | |
| SCHEMBL3405815 | 0.84 | MAPT (0.52) | POLBDRD2KDM4EDRD4 | |
| SCHEMBL3403888 | 0.84 | MAPT (0.53) | KMT2APOLBSMN1; SMN2RXFP1 | |
| SCHEMBL3399763 | 0.84 | CHRM4 (0.51) | KMT2APOLBDRD2KDM4EPOLR1A | |
| SCHEMBL3405818 | 0.84 | SMN1; SMN2 (0.46) | KMT2APOLBSMN1; SMN2ALDH1A1ALOX15 | |
| SCHEMBL3398904 | 0.83 | POLB (0.60) | POLBALDH1A1KDM4EHSD17B10 | |
| SCHEMBL3398788 | 0.83 | MAPT (0.48) | KMT2APOLBSMN1; SMN2ALDH1A1RXFP1 | |
| SCHEMBL3404043 | 0.83 | SMN1; SMN2 (0.60) | KMT2APOLBSMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |