Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | WNT1 | P04628 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402635 | 0.99 | MEN1 (0.47) | PARP1NPSR1MEN1KMT2ACHRM4 | |
| SCHEMBL13310019 | 0.89 | SRC (0.47) | PARP1NPSR1CHRM4NPC1HPGD | |
| SCHEMBL3403561 | 0.89 | WNT1 (0.52) | PARP1NPSR1MEN1KMT2ACHRM4 | |
| SCHEMBL3399888 | 0.87 | CHRM4 (0.45) | PARP1NPSR1KMT2ACHRM4LMNA | |
| SCHEMBL3404959 | 0.86 | CHRM4 (0.44) | PARP1NPSR1CHRM4LMNATSHR | |
| SCHEMBL3399342 | 0.85 | KMT2A (0.49) | PARP1KMT2APOLBALDH1A1 | |
| SCHEMBL3400096 | 0.83 | CHRM4 (0.49) | NPSR1CHRM4NPC1HPGDMAPT | |
| SCHEMBL3401313 | 0.82 | SCN9A (0.47) | PARP1NPSR1CHRM4TSHRSCN9A | |
| SCHEMBL3405409 | 0.82 | SCN9A (0.47) | PARP1NPSR1CHRM4TSHRSCN9A | |
| SCHEMBL3400929 | 0.82 | SCN9A (0.49) | NPSR1CHRM4NPC1HPGDWNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |