Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.64 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.64 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 15/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 15/20 | 0.48 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.43 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL733525 | 0.88 | PIK3CD (0.73) | PIK3CDPIK3R1PIK3CBPIK3CGHSP90AA1 | |
| SCHEMBL733101 | 0.80 | PIK3CD (0.80) | PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL733252 | 0.79 | PIK3CD (0.68) | PIK3CDPIK3R1PIK3CBPIK3CGGAA | |
| SCHEMBL4160767 | 0.79 | PIK3CD (0.73) | PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL733537 | 0.79 | PIK3CD (0.68) | PIK3CDPIK3R1PIK3CBPIK3CGGAA | |
| SCHEMBL734208 | 0.76 | PIK3CD (0.88) | PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL3398713 | 0.75 | PIK3CD (0.67) | PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL733420 | 0.74 | PIK3CD (0.82) | PIK3CDPIK3R1PIK3CBPIK3CG | |
| SCHEMBL4149819 | 0.74 | PIK3CD (0.54) | PIK3CDPIK3R1PIK3CBPIK3CGGAA | |
| SCHEMBL360745 | 0.72 | PIK3CD (1.00) | PIK3CDPIK3R1PIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8492389-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2013-07-23 | — | — | US | disclosed |
| US-20100152211-A1 | INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152211-A1 | INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PIK3CG | PIK3CD 1/4885PIK3R1 12/4885PIK3CB 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.