Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 12/20 | 0.68 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.60 |
| ▸ | PDE4A | P27815 | 3/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
| ▸ | PDE5A | O76074 | 2/20 | 0.44 |
| ▸ | PDE1A | P54750 | 2/20 | 0.44 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL733251 | 0.88 | PIK3CD (0.77) | PIK3CDPIK3R1PIK3CBPIK3CGPDE4A | |
| SCHEMBL3398713 | 0.88 | PIK3CD (0.67) | PIK3CDPIK3R1PIK3CBPIK3CGPDE4A | |
| SCHEMBL733537 | 0.86 | PIK3CD (0.68) | PIK3CDPIK3R1PIK3CBPIK3CGGAA | |
| SCHEMBL3399490 | 0.79 | PIK3CD (0.64) | PIK3CDPIK3R1PIK3CBPIK3CGGAA | |
| SCHEMBL17185514 | 0.79 | PIK3CD (0.73) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL4160767 | 0.79 | PIK3CD (0.73) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL734026 | 0.78 | PIK3CD (0.71) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL4149819 | 0.75 | PIK3CD (0.54) | PIK3CDPIK3R1PIK3CBPIK3CGGAA | |
| SCHEMBL360745 | 0.75 | PIK3CD (1.00) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL29358478 | 0.75 | PIK3CD (1.00) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8138195-B2 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2012-03-20 | — | — | US | disclosed |
| US-20050261317-A1 | Inhibitors of human phosphatidylinositol 3-kinase delta | ICOS CORPORATION (US) | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261317-A1 | Inhibitors of human phosphatidylinositol 3-kinase delta | PIK3CD, PIK3R5, PIK3CA | PIK3CD 1/4885PIK3R1 20/4885PIK3CB 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.