Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 18/20 | 0.73 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.73 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.65 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | PI4KA | P42356 | 1/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL733839 | 0.87 | PIK3CD (0.75) | PIK3CDPIK3R1PIK3CBPIK3CGADORA2A | |
| SCHEMBL733167 | 0.87 | PIK3CD (0.86) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL18526808 | 0.86 | PIK3CD (0.66) | PIK3CDPIK3R1PIK3CBPIK3CGADORA2A | |
| SCHEMBL734208 | 0.84 | PIK3CD (0.88) | PIK3CDPIK3R1PIK3CBPIK3CGPIK3CA | |
| SCHEMBL733097 | 0.84 | PIK3CD (0.70) | PIK3CDPIK3R1PIK3CBPIK3CGADORA2A | |
| SCHEMBL732491 | 0.83 | PIK3CD (0.69) | PIK3CDPIK3R1PIK3CBPIK3CGADORA2A | |
| SCHEMBL733332 | 0.83 | PIK3CD (0.69) | PIK3CDPIK3R1PIK3CBPIK3CGADORA2A | |
| SCHEMBL734943 | 0.82 | PIK3CD (0.67) | PIK3CDPIK3R1PIK3CBPIK3CGADORA2A | |
| SCHEMBL733199 | 0.80 | PIK3CD (0.70) | PIK3CDPIK3R1PIK3CBPIK3CGADORA2A | |
| SCHEMBL3399490 | 0.79 | PIK3CD (0.64) | PIK3CDPIK3R1PIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090131424-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-05-21 | — | — | US | disclosed |
| US-20090093474-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | GRAUERT MATTHIAS | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131424-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | CYP3A7, UGT2B7, UGT1A7 | PIK3CD 4737/4885PIK3R1 4578/4885PIK3CB 4786/4885 |
| US-20090093474-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | CYP3A43, CYP3A5, UGT1A3 | PIK3CD 3955/4885PIK3R1 4186/4885PIK3CB 4374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.