Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404377 | 0.89 | TRPM8 (0.57) | CNR1HTR2CKMT2ATRPM8SMN1; SMN2 | |
| SCHEMBL3399653 | 0.89 | CNR1 (0.54) | CNR1HTR2CKMT2ATHRATHRB | |
| SCHEMBL3404912 | 0.89 | CNR1 (0.51) | CNR1HTR2CTHRATHRBSMN1; SMN2 | |
| SCHEMBL3401781 | 0.89 | CNR1 (0.70) | CNR1HTR2CKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3404549 | 0.88 | CNR1 (0.53) | CNR1HTR2CKMT2ATHRATHRB | |
| SCHEMBL3402546 | 0.88 | CNR1 (0.53) | CNR1HTR2CKMT2ATHRATHRB | |
| SCHEMBL3399780 | 0.87 | CNR1 (0.54) | CNR1HTR2CKMT2ATHRATHRB | |
| SCHEMBL3405128 | 0.87 | CNR1 (0.52) | CNR1HTR2CKMT2ATHRATHRB | |
| SCHEMBL3403374 | 0.87 | CNR1 (0.52) | CNR1HTR2CKMT2ATHRATHRB | |
| SCHEMBL3402418 | 0.86 | ALDH1A1 (0.63) | CNR1HTR2CKMT2ATHRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |