Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.38 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.38 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13748769 | 0.88 | NR1H2 (0.50) | NR1H2PRMT5WDR77DDB1CRBN | |
| SCHEMBL22907300 | 0.83 | NR1H2 (0.51) | NR1H2PRMT5WDR77NAMPTGPR119 | |
| SCHEMBL22907301 | 0.82 | NR1H2 (0.47) | NR1H2PRMT5WDR77DDB1CRBN | |
| SCHEMBL27097891 | 0.82 | NR1H2 (0.54) | NR1H2PRMT5WDR77NAMPTGPR119 | |
| SCHEMBL27097890 | 0.82 | NR1H2 (0.50) | NR1H2PRMT5WDR77NAMPTGPR119 | |
| SCHEMBL3401258 | 0.81 | ITGB3 (0.40) | TPSAB1TPSD1TPSG1 | |
| SCHEMBL27097889 | 0.81 | NR1H2 (0.49) | NR1H2PRMT5WDR77NAMPTGPR119 | |
| SCHEMBL27097888 | 0.81 | NR1H2 (0.49) | NR1H2PRMT5WDR77NAMPTGPR119 | |
| SCHEMBL27136519 | 0.81 | NR1H2 (0.49) | NR1H2PRMT5WDR77NAMPTGPR119 | |
| SCHEMBL18921586 | 0.80 | NR1H2 (0.54) | NR1H2DDB1CRBNNAMPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252613-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM, LLC (BM) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009105717-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2009-08-27 | — | — | WO | disclosed |