Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402191 | 0.90 | TP53 (0.45) | HTR2CALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL3403006 | 0.87 | HTR2C (0.49) | HTR2CALDH1A1KMT2AHPGDMEN1 | |
| SCHEMBL3403442 | 0.87 | HTR2C (0.43) | HTR2CALDH1A1KMT2AMEN1KDM4E | |
| SCHEMBL3402439 | 0.86 | HTR2C (0.46) | HTR2CALDH1A1KDM4ECES2NPC1 | |
| SCHEMBL3405089 | 0.84 | HTR2C (0.46) | HTR2CALDH1A1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3405361 | 0.83 | RAB9A (0.53) | HTR2CALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL3405416 | 0.81 | HTR2C (0.48) | HTR2CKMT2AMEN1CES2L3MBTL1 | |
| SCHEMBL3399875 | 0.81 | HTR2C (0.48) | HTR2CKMT2AMEN1CES2L3MBTL1 | |
| SCHEMBL3404365 | 0.80 | HTR2C (0.42) | HTR2CKMT2AMEN1CES2L3MBTL1 | |
| SCHEMBL13310335 | 0.80 | HTR2C (0.43) | HTR2CALDH1A1KMT2AHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |