Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3406038 | 0.85 | HTR2C (0.47) | HTR2CCNR1THRATHRBCES2 | |
| SCHEMBL3407762 | 0.85 | HTR2C (0.47) | HTR2CCNR1THRATHRBCES2 | |
| SCHEMBL3402068 | 0.83 | HTR2C (0.47) | HTR2CCNR1THRATHRBCES2 | |
| SCHEMBL3405297 | 0.83 | HTR2C (0.43) | HTR2CCNR1THRATHRBMEN1 | |
| SCHEMBL3406010 | 0.83 | CNR1 (0.49) | HTR2CCNR1THRATHRBPARP1 | |
| SCHEMBL3396826 | 0.82 | HTR2C (0.46) | HTR2CCNR1CHRNA7PARP1HRH3 | |
| SCHEMBL3404209 | 0.82 | HTR2C (0.49) | HTR2CCNR1THRATHRBCES2 | |
| SCHEMBL3405067 | 0.81 | HTR2C (0.47) | HTR2CCNR1THRATHRBCES2 | |
| SCHEMBL3404163 | 0.81 | HTR2C (0.47) | HTR2CCNR1CES2CHRNA7HRH3 | |
| SCHEMBL3401691 | 0.80 | HTR2C (0.45) | HTR2CCNR1HRH3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |