Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | MC4R | P32245 | 1/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402966 | 0.89 | MEN1 (0.39) | MEN1KMT2AKDM4ELMNAALDH1A1 | |
| SCHEMBL3405179 | 0.87 | LMNA (0.38) | MEN1KMT2AKDM4ELMNAALDH1A1 | |
| SCHEMBL3402431 | 0.85 | CCND1 (0.40) | MEN1KMT2AKDM4ELMNACCND1 | |
| SCHEMBL3398731 | 0.84 | LMNA (0.38) | MEN1KMT2AKDM4ELMNAALDH1A1 | |
| SCHEMBL3404020 | 0.83 | LMNA (0.38) | MEN1KMT2AKDM4ELMNAALDH1A1 | |
| SCHEMBL3399762 | 0.81 | KMT2A (0.45) | MEN1KMT2AKDM4ELMNAALDH1A1 | |
| SCHEMBL3402347 | 0.81 | LMNA (0.36) | MEN1KMT2AKDM4ELMNAALDH1A1 | |
| SCHEMBL3405131 | 0.77 | TLR8 (0.43) | MEN1KMT2AKDM4ELMNAPOLB | |
| SCHEMBL3404354 | 0.74 | SIGMAR1 (0.46) | KDM4ELMNAALDH1A1TMEM97SIGMAR1 | |
| SCHEMBL3399827 | 0.74 | SIGMAR1 (0.43) | KDM4ELMNAALDH1A1TMEM97SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |