Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399741 | 0.89 | TRPM8 (0.50) | HTR2CTRPM8KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3404304 | 0.87 | KMT2A (0.61) | HTR2CTRPM8KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3403618 | 0.87 | TRPM8 (0.48) | HTR2CTRPM8KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3400834 | 0.87 | TRPM8 (0.46) | HTR2CTRPM8KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3404127 | 0.86 | HTR2C (0.49) | HTR2CTRPM8KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3398358 | 0.86 | KMT2A (0.48) | HTR2CTRPM8KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3402390 | 0.85 | HTR2C (0.46) | HTR2CTRPM8KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3404513 | 0.85 | HTR2C (0.46) | HTR2CTRPM8KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3397100 | 0.85 | HTR2C (0.46) | HTR2CTRPM8KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3405267 | 0.85 | ALDH1A1 (0.63) | HTR2CTRPM8KMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |