Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 4/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.40 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.40 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400900 | 0.89 | CHRM4 (0.54) | CHRM4CHRM3ACKR3PPARAPPARD | |
| SCHEMBL3405198 | 0.86 | CHRM4 (0.67) | CHRM4CHRM3ACKR3PPARANPC1 | |
| SCHEMBL3405324 | 0.85 | CHRM4 (0.51) | CHRM4PPARANPC1ALDH1A1GAA | |
| SCHEMBL3401222 | 0.85 | CHRM4 (0.56) | CHRM4CHRM3ACKR3PPARANPC1 | |
| SCHEMBL3405413 | 0.85 | CHRM4 (0.53) | CHRM4CHRM3ACKR3PPARANPC1 | |
| SCHEMBL13310232 | 0.85 | CHRM4 (0.57) | CHRM4CHRM3ACKR3PPARANPC1 | |
| SCHEMBL3403391 | 0.84 | CHRM4 (0.50) | CHRM4PPARANPC1ALDH1A1GAA | |
| SCHEMBL3401105 | 0.84 | CHRM4 (0.49) | CHRM4PPARANPC1ALDH1A1GAA | |
| SCHEMBL3405526 | 0.84 | PPARD (0.53) | CHRM4CHRM3ACKR3PPARANPC1 | |
| SCHEMBL3400884 | 0.84 | CHRM4 (0.54) | CHRM4CHRM3ACKR3PPARAPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |