Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PPARA | Q07869 | 3/20 | 0.55 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.51 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GHSR | Q92847 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405198 | 0.89 | CHRM4 (0.67) | CHRM4ALDH1A1PPARAACKR3CHRM3 | |
| SCHEMBL3398440 | 0.89 | ACKR3 (0.51) | CHRM4PPARAACKR3CHRM3NPC1 | |
| SCHEMBL3400075 | 0.87 | ACKR3 (0.54) | CHRM4ALDH1A1PPARAACKR3CHRM3 | |
| SCHEMBL3402412 | 0.86 | ACKR3 (0.53) | CHRM4PPARAACKR3NPC1PPARD | |
| SCHEMBL3402209 | 0.85 | ACKR3 (0.52) | CHRM4ALDH1A1SMN1; SMN2PPARAACKR3 | |
| SCHEMBL3399976 | 0.85 | ACKR3 (0.52) | CHRM4ALDH1A1SMN1; SMN2PPARAACKR3 | |
| SCHEMBL3404196 | 0.85 | ALDH1A1 (0.60) | CHRM4ALDH1A1SMN1; SMN2PPARAMEN1 | |
| SCHEMBL3400988 | 0.85 | CHRM4 (0.53) | CHRM4ALDH1A1PPARAACKR3CHRM3 | |
| SCHEMBL3405413 | 0.85 | CHRM4 (0.53) | CHRM4ALDH1A1PPARAACKR3CHRM3 | |
| SCHEMBL3402424 | 0.85 | ACKR3 (0.50) | CHRM4PPARAACKR3NPC1PPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |