Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL340103

CC(=O)O[C@@](C)(N)Cc1ccccc1.N

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 1/20 0.52
TAAR1 Q96RJ0 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52
HIF1A Q16665 1/20 0.52
ALDH1A1 P00352 4/20 0.49
RECQL P46063 2/20 0.49
CYP3A4 P08684 2/20 0.43
CYP1A2 P05177 2/20 0.43
MMP8 P22894 4/20 0.42
BLM P54132 1/20 0.42
PPARG P37231 1/20 0.42
PPARA Q07869 1/20 0.42
MAPK1 P28482 1/20 0.42
CYP2C9 P11712 2/20 0.41
CYP2C19 P33261 2/20 0.41
CYP2D6 P10635 2/20 0.40
SLC1A3 P43003 2/20 0.40
SLC1A2 P43004 2/20 0.40
SLC1A1 P43005 2/20 0.40
MEN1 O00255 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL111212 0.81 ALDH1A1 (0.50) SLC6A2TAAR1SMN1; SMN2HIF1AALDH1A1
SCHEMBL27893238 0.81 KCNH2 (0.50) SLC6A2TAAR1SMN1; SMN2HIF1AALDH1A1
SCHEMBL27947462 0.81 SMN1; SMN2 (0.50) SLC6A2TAAR1SMN1; SMN2HIF1AALDH1A1
Hydrochloric Acid SCHEMBL27976122 0.79 OPRM1 (0.51) SLC6A2TAAR1SMN1; SMN2HIF1AALDH1A1
SCHEMBL2878828 0.79 PPARG (0.56) SLC6A2TAAR1SMN1; SMN2HIF1AALDH1A1
SCHEMBL29156976 0.78 SMN1; SMN2 (0.47) SLC6A2TAAR1SMN1; SMN2HIF1AALDH1A1
SCHEMBL25840112 0.78 ALDH1A1 (0.50) SLC6A2TAAR1SMN1; SMN2HIF1AALDH1A1
SCHEMBL24193177 0.78 ALDH1A1 (0.56) SLC6A2SMN1; SMN2ALDH1A1CYP3A4CYP1A2
SCHEMBL237343 0.77 ALDH1A1 (0.46) SLC6A2TAAR1SMN1; SMN2HIF1AALDH1A1
SCHEMBL7195667 0.77 ALDH1A1 (0.46) SLC6A2TAAR1SMN1; SMN2HIF1AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9181175-B2 Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid Zhejiang Jiuzhous Pharmaceutical Co., Ltd. (CN) 2015-11-10 US disclosed
EP-2387558-B1 PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID ZHEJIANG JIUZHOU PHARM CO LTD (CN) 2014-08-27 EP disclosed
US-20140179947-A1 PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) 2014-06-26 US disclosed
US-8703990-B2 Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid Zhejiang Jiuzhous Pharmaceutical Co., Ltd. (CN) 2014-04-22 US disclosed
US-20120016151-A1 PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID NOVARTIS AG (CH) 2012-01-19 US disclosed
EP-2387558-A1 PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID Zhejiang Jiuzhou Pharmaceutical Co., Ltd. (CN) 2011-11-23 EP disclosed
US-20110253230-A1 Temperature Sensitive Valve Having Shape Memory Actuator OMNITEK PARTNERS LLC (US) 2011-10-20 US disclosed
WO-2010081410-A1 PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) 2010-07-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140179947-A1 PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID DNPEP, MME, DPP7 SLC6A2 2035/4885TAAR1 2930/4885SMN1; SMN2 3020/4885
US-20120016151-A1 PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID DNPEP, MME, DPP7 SLC6A2 2035/4885TAAR1 2930/4885SMN1; SMN2 3020/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.