Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | RBP4 | P02753 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | OXTR | P30559 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404419 | 0.94 | HTR2C (0.51) | HTR2CCNR1CES2PPARDPPARA | |
| SCHEMBL3400812 | 0.92 | HTR2C (0.53) | HTR2CCNR1CES2PPARDPPARA | |
| SCHEMBL3405718 | 0.89 | HTR2C (0.58) | HTR2CCNR1CES2OXTRPOLB | |
| SCHEMBL13310193 | 0.88 | HTR2C (0.51) | HTR2CCNR1CES2PPARDPPARA | |
| SCHEMBL3398163 | 0.88 | HTR2C (0.57) | HTR2CCNR1CES2OXTRPOLB | |
| SCHEMBL3399813 | 0.87 | HTR2C (0.56) | HTR2CCNR1CES2PPARDPPARA | |
| SCHEMBL3402631 | 0.86 | HTR2C (0.74) | HTR2CCNR1CES2 | |
| SCHEMBL3405059 | 0.85 | HTR2C (0.56) | HTR2CCNR1CES2CYP2C9CYP2C19 | |
| SCHEMBL3400102 | 0.85 | HTR2C (0.54) | HTR2CCNR1CES2OXTRPOLB | |
| SCHEMBL3402583 | 0.85 | HTR2C (0.53) | HTR2CCNR1PPARDPPARAMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |