Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.42 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404419 | 0.89 | HTR2C (0.51) | HTR2CMCHR1CNR1SCD5PPARD | |
| SCHEMBL3400023 | 0.86 | HTR2C (0.73) | HTR2CCNR1PARP1 | |
| SCHEMBL3405516 | 0.86 | HTR2C (0.53) | HTR2CPDK2CNR1HRH3 | |
| SCHEMBL3403464 | 0.85 | HTR2C (0.52) | HTR2CPDK2MCHR1CNR1HRH3 | |
| SCHEMBL3401147 | 0.85 | HTR2C (0.55) | HTR2CMCHR1CNR1SCD5PPARD | |
| SCHEMBL3399443 | 0.85 | HTR2C (0.54) | HTR2CPDK2CNR1HRH3PARP1 | |
| SCHEMBL3399878 | 0.84 | HTR2C (0.58) | HTR2CPDK2CNR1HRH3PARP1 | |
| SCHEMBL3400812 | 0.83 | HTR2C (0.53) | HTR2CMCHR1CNR1SCD5PPARD | |
| SCHEMBL13344919 | 0.83 | HTR2C (0.50) | HTR2CPDK2CNR1SCD5PPARD | |
| SCHEMBL13310179 | 0.81 | HTR2C (0.58) | HTR2CCNR1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |