Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | MTOR | P42345 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22032727 | 0.92 | NPC1 (0.53) | NPC1MTORRAB9ASIRT2KDM4E | |
| SCHEMBL24236985 | 0.86 | KDM4E (0.51) | NPC1MTORRAB9ASIRT2KDM4E | |
| SCHEMBL22032687 | 0.86 | NPC1 (0.46) | NPC1MTORRAB9ASIRT2KDM4E | |
| SCHEMBL7067927 | 0.83 | RAB9A (0.78) | NPC1MTORRAB9ASIRT2KDM4E | |
| SCHEMBL7064269 | 0.82 | RAB9A (0.72) | NPC1MTORRAB9ASIRT2KDM4E | |
| SCHEMBL24299238 | 0.81 | ALDH1A1 (0.46) | NPC1MTORRAB9ASIRT2KDM4E | |
| SCHEMBL22032792 | 0.80 | KDM4E (0.48) | NPC1MTORRAB9ASIRT2KDM4E | |
| SCHEMBL22078652 | 0.80 | KDM4E (0.45) | NPC1MTORRAB9ASIRT2KDM4E | |
| SCHEMBL8650828 | 0.80 | RAB9A (0.82) | NPC1MTORRAB9ASIRT2ALDH1A1 | |
| SCHEMBL22079198 | 0.80 | ALDH1A1 (0.48) | NPC1MTORRAB9ASIRT2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8158438-B2 | Method for the determination of the concentration of a non-volatile analyte | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2012-04-17 | — | — | US | disclosed |
| US-8097725-B2 | Luminescent indicator dye and optical sensor | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2012-01-17 | — | — | US | disclosed |
| EP-1899712-B1 | METHOD FOR THE DETERMINATION OF THE CONCENTRATION OF A NON-VOLATILE ANALYTE | HOFFMANN LA ROCHE (CH) | 2010-11-24 | — | — | EP | disclosed |
| EP-1817290-B1 | LUMINESCENT INDICATOR DYE AND OPTICAL SENSOR | ROCHE DIAGNOSTICS GMBH (DE) | 2008-11-12 | — | — | EP | disclosed |
| US-20080215254-A1 | Method for the Determination of the Concentration of a Non-Volatile Analyte | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2008-09-04 | — | — | US | disclosed |
| EP-1899712-A1 | METHOD FOR THE DETERMINATION OF THE CONCENTRATION OF A NON-VOLATILE ANALYTE | F. Hoffmann-Roche AG (CH) | 2008-03-19 | — | — | EP | disclosed |
| EP-1817290-A2 | LUMINESCENT INDICATOR DYE AND OPTICAL SENSOR | Roche Diagnostics GmbH (DE) | 2007-08-15 | — | — | EP | disclosed |
| WO-2007006454-A1 | METHOD FOR THE DETERMINATION OF THE CONCENTRATION OF A NON-VOLATILE ANALYTE | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-18 | — | — | WO | disclosed |
| EP-1742039-A1 | Method for the determination of the concentration of a non-volatile analyte | F. Hoffmann-La Roche Ltd. (CH) | 2007-01-10 | — | — | EP | disclosed |
| US-20060121623-A1 | Luminescent indicator dye and optical sensor | ROCHE DIAGNOSTICS OPERATIONS, INC. | 2006-06-08 | — | — | US | disclosed |
| WO-2006058778-A2 | LUMINESCENT INDICATOR DYE AND OPTICAL SENSOR | ROCHE DIAGNOSTICS GMBH (DE) | 2006-06-08 | — | — | WO | disclosed |