Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | FBP1 | P09467 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | CDC7 | O00311 | 3/20 | 0.47 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3397941 | 0.86 | ALDH1A1 (0.51) | ALDH1A1HSD17B10KDM4EMEN1MAPT | |
| SCHEMBL330552 | 0.80 | ALDH1A1 (1.00) | ALDH1A1HSD17B10KDM4EMEN1MAPT | |
| SCHEMBL18236334 | 0.78 | ALDH1A1 (0.69) | ALDH1A1HSD17B10KDM4EMEN1KMT2A | |
| SCHEMBL17844008 | 0.77 | ALDH1A1 (0.70) | ALDH1A1HSD17B10KDM4EMEN1MAPT | |
| Ethyl Acetate SCHEMBL27662923 | 0.76 | CYP1A2 (0.59) | ALDH1A1HSD17B10KDM4EMEN1MAPT | |
| SCHEMBL11163073 | 0.76 | ALDH1A1 (0.69) | ALDH1A1HSD17B10KDM4EMAPTCYP1A2 | |
| SCHEMBL4298781 | 0.75 | RARA (0.64) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL694406 | 0.75 | NPSR1 (0.66) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL28719271 | 0.75 | ALDH1A1 (0.67) | ALDH1A1HSD17B10KDM4EMEN1MAPT | |
| SCHEMBL1505583 | 0.75 | ALDH1A1 (0.67) | ALDH1A1HSD17B10KDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158199-B1 | PIPERIDINE COMPOUNDS AND USES THEREOF | ASTRAZENECA AB (SE) | 2010-11-17 | — | — | EP | disclosed |
| EP-2158199-B1 | PIPERIDINE COMPOUNDS AND USES THEREOF | ASTRAZENECA AB (SE) | 2010-11-17 | — | — | EP | disclosed |
| WO-2008152418-A1 | PIPERIDINE COMPOUNDS AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-12-18 | — | — | WO | disclosed |