Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 5/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402406 | 0.89 | HTR2C (0.40) | HTR2CCRHR1RAB9AKDM4EGAA | |
| SCHEMBL13071984 | 0.89 | HTR2C (0.40) | HTR2CCRHR1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL13310314 | 0.88 | HTR2C (0.41) | HTR2CCRHR1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL13071483 | 0.87 | HTR2C (0.40) | HTR2CCRHR1RAB9AKDM4EGAA | |
| SCHEMBL3401729 | 0.84 | RAB9A (0.54) | RAB9AKDM4EGAASMN1; SMN2NPC1 | |
| SCHEMBL3402104 | 0.84 | HTR2C (0.53) | HTR2CRAB9AKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL3405333 | 0.83 | RAB9A (0.40) | HTR2CCRHR1RAB9AKDM4EGAA | |
| SCHEMBL3404329 | 0.83 | CRHR1 (0.44) | HTR2CCRHR1RAB9AKDM4EGAA | |
| SCHEMBL3400468 | 0.83 | HTR2C (0.40) | HTR2CCRHR1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL3402572 | 0.83 | HTR2C (0.48) | HTR2CCRHR1RAB9AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |