SCHEMBL340227

SCHEMBL340227

CC(C)(C)N[C@@H](CO)C(=O)c1cccc(Cl)c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 7/20 0.68
SLC6A3 Q01959 6/20 0.68
CHRNA1 P02708 4/20 0.68
CHRNG P07510 4/20 0.68
CHRNB1 P11230 4/20 0.68
CHRNB2 P17787 4/20 0.68
CHRNB4 P30926 4/20 0.68
CHRNA3 P32297 4/20 0.68
CHRNA4 P43681 4/20 0.68
CHRND Q07001 4/20 0.68
SLC6A4 P31645 3/20 0.68
ITGA5 P08648 1/20 0.68
CYP2C19 P33261 1/20 0.68
HRH1 P35367 1/20 0.68
CHRNA7 P36544 1/20 0.68
OPRK1 P41145 1/20 0.68
KCNH2 Q12809 1/20 0.68
ALDH1A1 P00352 3/20 0.66
BLM P54132 1/20 0.66
SMN1; SMN2 Q16637 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1686427 1.00 SLC6A2 (0.68) SLC6A2SLC6A3CHRNA1CHRNGCHRNB1
SCHEMBL35211 1.00 SLC6A2 (0.68) SLC6A2SLC6A3CHRNA1CHRNGCHRNB1
Hydrochloric Acid SCHEMBL12497918 0.99 SLC6A2 (0.68) SLC6A2SLC6A3CHRNA1CHRNGCHRNB1
SCHEMBL770048 0.89 SLC6A2 (0.68) SLC6A2SLC6A3CHRNA1CHRNGCHRNB1
SCHEMBL769847 0.86 SLC6A2 (0.64) SLC6A2SLC6A3CHRNA1CHRNGCHRNB1
SCHEMBL4874443 0.86 SLC6A2 (0.64) SLC6A2SLC6A3CHRNA1CHRNGCHRNB1
SCHEMBL13151517 0.86 SLC6A2 (0.68) SLC6A2SLC6A3CHRNA1CHRNGCHRNB1
SCHEMBL634045 0.84 SLC6A2 (0.61) SLC6A2SLC6A3CHRNA1CHRNGCHRNB1
SCHEMBL769133 0.84 SLC6A2 (0.61) SLC6A2SLC6A3CHRNA1CHRNGCHRNB1
SCHEMBL633272 0.83 SLC6A2 (0.60) SLC6A2SLC6A3CHRNA1CHRNGCHRNB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 257 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11660274-B2 Dosage forms and methods for enantiomerically enriched or pure bupropion AXSOME THERAPEUTICS, INC. (US) 2023-05-30 US claimed
US-20220249406-A1 DOSAGE FORMS AND METHODS FOR ENANTIOMERICALLY ENRICHED OR PURE BUPROPION WILMINGTON TRUST, NATIONAL ASSOCIATION 2022-08-11 US claimed
US-11331285-B2 Dosage forms and methods for enantiomerically enriched or pure bupropion AXSOME THERAPEUTICS, INC. (US) 2022-05-17 US claimed
EP-3755312-A1 DOSAGE FORMS AND METHODS FOR ENANTIOMERICALLY ENRICHED OR PURE BUPROPION Axsome Therapeutics, Inc. (US) 2020-12-30 EP claimed
US-20200222339-A1 DOSAGE FORMS AND METHODS FOR ENANTIOMERICALLY ENRICHED OR PURE BUPROPION AXSOME THERAPEUTICS, INC. 2020-07-16 US claimed
US-20200222342-A1 DOSAGE FORMS AND METHODS FOR ENANTIOMERICALLY ENRICHED OR PURE BUPROPION AXSOME THERAPEUTICS, INC. 2020-07-16 US claimed
US-20200093760-A1 DOSAGE FORMS AND METHODS FOR ENANTIOMERICALLY ENRICHED OR PURE BUPROPION AXSOME THERAPEUTICS, INC. 2020-03-26 US claimed
WO-2020061486-A2 DOSAGE FORMS AND METHODS FOR ENANTIOMERICALLY ENRICHED OR PURE BUPROPION AXSOME THERAPEUTICS, INC. (US) 2020-03-26 WO claimed
WO-2019165379-A1 DOSAGE FORMS AND METHODS FOR ENANTIOMERICALLY ENRICHED OR PURE BUPROPION AXSOME THERAPEUTICS, INC. (US) 2019-08-29 WO claimed
US-20190216801-A1 DOSAGE FORMS AND METHODS FOR ENANTIOMERICALLY ENRICHED OR PURE BUPROPION AXSOME THERAPEUTICS, INC. 2019-07-18 US claimed
US-20050176680-A1 Eszopiclone stimulates GABA receptors, and serotonin reuptake inhibitor (citalopram), norepinephrine reuptake inhibitor (desipramine), 5-HT2A modulator, or dopamine reuptake inhibitor (amineptine) SEPRACOR, INC. (US) 2005-08-11 US claimed
WO-2005060968-A1 COMBINATION OF A SEDATIVE AND A NEUROTRANSMITTER MODULATOR, AND METHODS FOR IMPROVING SLEEP QUALITY AND TREATING DEPRESSION SEPRACOR INC. (US) 2005-07-07 WO claimed
JP-2004513061-A 2004-04-30 JP claimed
EP-1259243-A2 BUPROPION METABOLITES AND METHODS OF THEIR SYNTHESIS AND USE SEPRACOR, INC. (US) 2002-11-27 EP claimed
US-20020052340-A1 Bupropion metabolites and methods of their synthesis and use JERUSSI THOMAS P (US) 2002-05-02 US claimed
US-20020052341-A1 Bupropion metabolites and methods of their synthesis and use SEPRACOR INC. 2002-05-02 US claimed
US-6342496-B1 BRAIN DISORDERS SEPRACOR INC. 2002-01-29 US claimed
EP-1165086-A2 BUPROPION METABOLITES AND METHODS OF THEIR SYNTHESIS AND USE Sepracor Inc. (US) 2002-01-02 EP claimed
WO-2001062257-A2 BUPROPION METABOLITES AND METHODS OF THEIR SYNTHESIS AND USE SEPRACOR INC. (US) 2001-08-30 WO claimed
WO-2000051546-A2 BUPROPION METABOLITES AND METHODS OF THEIR SYNTHESIS AND USE SEPRACOR INC. (US) 2000-09-08 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020052341-A1 Bupropion metabolites and methods of their synthesis and use MAOB, MAOA, HTR5A SLC6A2 6/4885SLC6A3 10/4885CHRNA1 86/4885
US-20050176680-A1 Eszopiclone stimulates GABA receptors, and serotonin reuptake inhibitor (citalopram), norepinephrine reuptake inhibitor (desipramine), 5-HT2A modulator, or dopamine reuptake inhibitor (amineptine) HTR2A, HTR2C, HTR5A SLC6A2 11/4885SLC6A3 35/4885CHRNA1 74/4885
US-20200093760-A1 DOSAGE FORMS AND METHODS FOR ENANTIOMERICALLY ENRICHED OR PURE BUPROPION CYP2D6, CYP3A5, CYP2B6 SLC6A2 7/4885SLC6A3 12/4885CHRNA1 213/4885
US-20220249406-A1 DOSAGE FORMS AND METHODS FOR ENANTIOMERICALLY ENRICHED OR PURE BUPROPION CYP2D6, CYP3A5, CYP2B6 SLC6A2 7/4885SLC6A3 12/4885CHRNA1 213/4885
US-20200222342-A1 DOSAGE FORMS AND METHODS FOR ENANTIOMERICALLY ENRICHED OR PURE BUPROPION CYP2D6, CYP3A5, CYP2B6 SLC6A2 7/4885SLC6A3 12/4885CHRNA1 213/4885
US-20200222339-A1 DOSAGE FORMS AND METHODS FOR ENANTIOMERICALLY ENRICHED OR PURE BUPROPION CYP2D6, CYP3A5, CYP2B6 SLC6A2 7/4885SLC6A3 12/4885CHRNA1 213/4885
US-11331285-B2 Dosage forms and methods for enantiomerically enriched or pure bupropion CYP2D6, CYP3A5, CYP2B6 SLC6A2 7/4885SLC6A3 12/4885CHRNA1 213/4885
US-20190216801-A1 DOSAGE FORMS AND METHODS FOR ENANTIOMERICALLY ENRICHED OR PURE BUPROPION CYP2D6, DBH, CYP3A43 SLC6A2 31/4885SLC6A3 21/4885CHRNA1 246/4885
US-20020052340-A1 Bupropion metabolites and methods of their synthesis and use MAOB, MAOA, HTR5A SLC6A2 4/4885SLC6A3 11/4885CHRNA1 76/4885
US-11660274-B2 Dosage forms and methods for enantiomerically enriched or pure bupropion CYP2D6, CYP3A5, CYP2B6 SLC6A2 7/4885SLC6A3 12/4885CHRNA1 213/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.