Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400977 | 0.87 | CYP4F2 (0.55) | CYP4A11CYP4F2MAPTCA1CA2 | |
| SCHEMBL3396943 | 0.85 | CA12 (0.49) | MAPTCA1CA2TDP1CA12 | |
| SCHEMBL13543623 | 0.81 | LOXL2 (0.56) | LOXL2CYP4A11CYP4F2MAPTCA1 | |
| SCHEMBL2653884 | 0.81 | LOXL2 (0.56) | LOXL2CYP4A11CYP4F2MAPTCA1 | |
| SCHEMBL28295886 | 0.80 | LOXL2 (0.54) | LOXL2CYP4A11CYP4F2MAPTCA1 | |
| SCHEMBL765010 | 0.79 | LOXL2 (0.61) | LOXL2CYP4A11CYP4F2MAPTCA1 | |
| SCHEMBL24843670 | 0.78 | LOXL2 (0.53) | LOXL2CYP4A11CYP4F2MAPTCA1 | |
| SCHEMBL5177723 | 0.77 | LOXL2 (0.59) | LOXL2CYP4A11CYP4F2MAPTCA1 | |
| SCHEMBL378575 | 0.77 | LOXL2 (0.59) | LOXL2CYP4A11CYP4F2MAPTCA1 | |
| SCHEMBL14379749 | 0.77 | LOXL2 (0.51) | LOXL2CYP4A11CYP4F2MAPTCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170050-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | Milestone Pharmaceuticals Inc. (CA) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008156820-A1 | SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF | MILESTONE PHARMACEUTICALS INC. (CA) | 2008-12-24 | — | — | WO | disclosed |