SCHEMBL378575

SCHEMBL378575

COC(=O)c1ccc(CC#N)cc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 1/20 0.59
CYP4A11 Q02928 2/20 0.54
CYP4F2 P78329 1/20 0.53
CA1 P00915 3/20 0.52
CA2 P00918 3/20 0.52
TDP1 Q9NUW8 1/20 0.52
CA12 O43570 1/20 0.52
CA7 P43166 1/20 0.52
CA9 Q16790 1/20 0.52
CA14 Q9ULX7 1/20 0.52
MAPT P10636 2/20 0.52
MEN1 O00255 1/20 0.49
KMT2A Q03164 1/20 0.49
TSHR P16473 2/20 0.48
KDM4E B2RXH2 1/20 0.47
NPC1 O15118 1/20 0.47
ALDH1A1 P00352 1/20 0.47
GAA P10253 1/20 0.47
HPGD P15428 1/20 0.47
MAPK1 P28482 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4118556 0.89 NPC1 (0.62) MAPTMEN1KMT2AKDM4ENPC1
SCHEMBL21750396 0.84 PTPN11 (0.49) LOXL2CYP4A11CYP4F2CA1CA2
SCHEMBL6538872 0.83 LOXL2 (0.61) LOXL2CYP4A11CYP4F2CA1CA2
SCHEMBL6716160 0.82 CYP4A11 (0.60) LOXL2CYP4A11CYP4F2CA1CA2
SCHEMBL3967293 0.82 CA1 (0.58) CA1CA2TDP1CA12CA7
SCHEMBL13898526 0.81 CA12 (0.47) LOXL2CYP4A11CYP4F2CA1CA2
SCHEMBL935888 0.81 CA12 (0.47) LOXL2CYP4A11CYP4F2CA1CA2
SCHEMBL6877770 0.81 LOXL2 (0.59) LOXL2CYP4A11CYP4F2CA1CA2
SCHEMBL1368363 0.81 GPR119 (0.48) LOXL2CA1CA2CA12CA9
SCHEMBL29003606 0.80 LOXL2 (0.58) LOXL2CYP4A11CYP4F2CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 334 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250115684-A1 Method for Preparing Polyethylene Polymerization Catalyst SK INNOVATION CO., LTD. (KR) 2025-04-10 US claimed
EP-4534571-A1 METHOD FOR PREPARING POLYETHYLENE POLYMERIZATION CATALYST SK Innovation Co., Ltd. (KR) 2025-04-09 EP claimed
CN-119775460-A Process for preparing polyethylene polymerization catalyst SK新技术株式会社 2025-04-08 CN claimed
CN-118459780-A Circular polarization luminescent material with in-situ adjustability and preparation method thereof 苏州大学 2024-08-09 CN claimed
CN-115141117-A Preparation and application of aggregation-induced luminescent material with mechanochromism and photochromism 北京科技大学 2022-10-04 CN claimed
CN-216432339-U A drying and dehumidifying device for production of methyl p-cyanobenzoate 山东佰隆医药有限公司 2022-05-03 CN claimed
EP-3814355-B1 TRIAZOLOTRIAZINE DERIVATIVES AS A2A RECEPTOR ANTAGONISTS ZHEJIANG VIMGREEN PHARMACEUTICALS LTD (CN) 2025-12-24 EP disclosed
US-20250195462-A1 SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF MILESTONE PHARMACEUTICALS INC (CA) 2025-06-19 US disclosed
US-12297178-B2 Triazole derivative and use thereof GYEONGGIDO BUSINESS & SCIENCE ACCELERATOR (KR) 2025-05-13 US disclosed
US-20250115684-A1 Method for Preparing Polyethylene Polymerization Catalyst SK INNOVATION CO., LTD. (KR) 2025-04-10 US disclosed
EP-4534571-A1 METHOD FOR PREPARING POLYETHYLENE POLYMERIZATION CATALYST SK Innovation Co., Ltd. (KR) 2025-04-09 EP disclosed
CN-119775460-A Process for preparing polyethylene polymerization catalyst SK新技术株式会社 2025-04-08 CN disclosed
US-20240366552-A1 SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF MILESTONE PHARMACEUTICALS INC (CA) 2024-11-07 US disclosed
US-5145854-A 1-formyl-5,8,10-trideazafolates NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 1992-09-08 US disclosed
EP-0501876-A1 N-(3-pyridylalkyl)sulfonamide derivative and pharmaceutical preparation containing thereof TERUMO KABUSHIKI KAISHA (JP) 1992-09-02 EP disclosed
US-5135949-A Anticoagulants BOEHRINGER MANNHEIM GMBH (DE) 1992-08-04 US disclosed
US-4950732-A RADIATION RESISTANCE EASTMAN KODAK COMPANY 1990-08-21 US disclosed
EP-0272692-A2 Condensation copolymers containing bis-methine moieties and products therefrom EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1988-06-29 EP disclosed
US-4719203-A CALCIUM METABOLISM DISORDERS BOEHRINGER MANNHEIM GMBH (DE) 1988-01-12 US disclosed
US-4598077-A Amidine derivatives and cardiotonic compositions TORII & CO. LTD. (JP) 1986-07-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240366552-A1 SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF ORAI1, ATP2A1, RYR2 LOXL2 3496/4885CYP4A11 2712/4885CYP4F2 3383/4885
US-12297178-B2 Triazole derivative and use thereof FABP4, LIPC, GPR119 LOXL2 3840/4885CYP4A11 135/4885CYP4F2 1408/4885
US-20250195462-A1 SHORT ACTING PHENYLALKYLAMINE CALCIUM CHANNEL BLOCKERS AND USES THEREOF ORAI1, ATP2A1, RYR2 LOXL2 3496/4885CYP4A11 2712/4885CYP4F2 3383/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.