Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 5/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405106 | 0.92 | HRH3 (0.48) | HRH3HTR2CALDH1A1L3MBTL1KDM4E | |
| SCHEMBL3401600 | 0.92 | HRH3 (0.48) | HRH3HTR2CALDH1A1L3MBTL1KDM4E | |
| SCHEMBL3402627 | 0.91 | RAB9A (0.50) | NPC1RAB9AHTR2CPKMALDH1A1 | |
| SCHEMBL3405361 | 0.91 | RAB9A (0.53) | NPC1RAB9AHTR2CPKMALDH1A1 | |
| SCHEMBL3405124 | 0.89 | NPC1 (0.45) | NPC1RAB9AHTR2CPKMALDH1A1 | |
| SCHEMBL3405168 | 0.89 | HTR2C (0.46) | NPC1RAB9ASLC6A4HRH3HTR2C | |
| SCHEMBL3403991 | 0.87 | RAB9A (0.44) | NPC1RAB9AHTR2CPKMALDH1A1 | |
| SCHEMBL3401632 | 0.87 | HTR2C (0.46) | RAB9ASLC6A4HRH3HTR2CALDH1A1 | |
| SCHEMBL3400125 | 0.87 | HTR2C (0.56) | NPC1RAB9AHRH3HTR2CPKM | |
| SCHEMBL3397030 | 0.87 | HTR2C (0.46) | NPC1RAB9AHTR2CALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |