Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3405361 | 0.92 | RAB9A (0.53) | RAB9ANPC1PKMHTR2CALDH1A1 | |
| SCHEMBL3405147 | 0.91 | MEN1 (0.49) | HTR2CALDH1A1HPGDKMT2A | |
| SCHEMBL3401211 | 0.91 | MEN1 (0.49) | HTR2CALDH1A1HPGDKMT2A | |
| SCHEMBL3405124 | 0.91 | NPC1 (0.45) | RAB9ANPC1PKMHTR2CALDH1A1 | |
| SCHEMBL3402441 | 0.91 | NPC1 (0.47) | RAB9ANPC1PKMHTR2CALDH1A1 | |
| SCHEMBL3401305 | 0.89 | KMT2A (0.48) | RAB9ANPC1PKMHTR2CALDH1A1 | |
| SCHEMBL3403991 | 0.89 | RAB9A (0.44) | RAB9ANPC1PKMHTR2CALDH1A1 | |
| SCHEMBL3401271 | 0.89 | PKM (0.49) | RAB9ANPC1PKMHTR2CALDH1A1 | |
| SCHEMBL3400125 | 0.88 | HTR2C (0.56) | RAB9ANPC1PKMHTR2CALDH1A1 | |
| SCHEMBL3400850 | 0.86 | HTR2C (0.45) | RAB9ANPC1PKMHTR2CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |