SCHEMBL3402499

SCHEMBL3402499

COc1ccc(-c2nc(C)c(C(=O)NCCCN3CCCCC3C)s2)c(OC)c1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53
TSHR P16473 1/20 0.53
CYP2C19 P33261 1/20 0.53
HSD17B10 Q99714 1/20 0.51
RAB9A P51151 2/20 0.50
NPC1 O15118 1/20 0.50
HRH3 Q9Y5N1 2/20 0.46
CACNA1G O43497 8/20 0.46
THRB P10828 1/20 0.44
HDAC3 O15379 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC11 Q96DB2 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3400825 0.93 CYP1A2 (0.54) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL3400138 0.89 HSD17B10 (0.53) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL3400236 0.88 CYP1A2 (0.54) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL13071990 0.87 HSD17B10 (0.51) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL3401951 0.87 HSD17B10 (0.49) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL3406018 0.87 HSD17B10 (0.49) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL3400068 0.86 CYP1A2 (0.58) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL3399723 0.86 HSD17B10 (0.51) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL3405639 0.85 HSD17B10 (0.49) CYP1A2CYP2D6CYP2C9TSHRCYP2C19
SCHEMBL3402383 0.85 HSD17B10 (0.51) CYP1A2CYP2D6CYP2C9TSHRCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7728009-B1 Thiazole amides, imidazole amides and related analogues NEUROGEN CORPORATION (US) 2010-06-01 US disclosed
US-7728009-B1 Thiazole amides, imidazole amides and related analogues NEUROGEN CORPORATION (US) 2010-06-01 US disclosed
US-7728009-B1 Thiazole amides, imidazole amides and related analogues NEUROGEN CORPORATION (US) 2010-06-01 US disclosed
WO-2006089076-A9 THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES NEUROGEN CORP (US) 2007-04-26 WO disclosed