SCHEMBL3402558

SCHEMBL3402558

Nc1cccc(OC2(C#Cc3ccccc3)C=CC(C(=O)c3ccccc3)=CC2)c1

nearest known ligand 0.40

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PBRM1 Q86U86 1/20 0.40
MAOB P27338 1/20 0.32
FFAR1 O14842 1/20 0.31
STS P08842 1/20 0.31
ASIC3 Q9UHC3 1/20 0.30
MEN1 O00255 1/20 0.30
KMT2A Q03164 1/20 0.30
NPC1 O15118 1/20 0.30
MITF O75030 1/20 0.30
LMNA P02545 1/20 0.30
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9750704 0.81 PBRM1 (0.44) PBRM1MAOBSTSMEN1KMT2A
SCHEMBL29390518 0.81 PBRM1 (0.44) PBRM1MAOBSTSMEN1KMT2A
SCHEMBL29865804 0.81 PBRM1 (0.44) PBRM1MAOBSTSMEN1KMT2A
SCHEMBL28736781 0.71 ALDH1A1 (0.33) FFAR1MEN1KMT2ALMNA
SCHEMBL29191329 0.71 ALDH1A1 (0.35) PBRM1STSMEN1KMT2ANPC1
SCHEMBL7982722 0.69 PBRM1 (0.35) PBRM1MAOBFFAR1ASIC3
SCHEMBL30792557 0.68 SRD5A2 (0.36) STSMEN1KMT2ANPC1POLB
SCHEMBL1627987 0.68 PBRM1 (0.35) PBRM1STSMEN1KMT2ANPC1
SCHEMBL2154321 0.68 ALDH1A1 (0.37) STSMEN1KMT2ANPC1POLB
SCHEMBL528382 0.67 ALDH1A1 (0.42) PBRM1MEN1KMT2ANPC1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11407199-B2 Metal-coated fabrics for fiber-metal laminates THE BOEING COMPANY (US) 2022-08-09 US disclosed
WO-2010120426-A1 METAL-COATED FABRICS FOR FIBER-METAL LAMINATES THE BOEING COMPANY (US) 2010-10-21 WO disclosed
US-20100264266-A1 METAL-COATED FABRICS FOR FIBER-METAL LAMINATES THE BOEING COMPANY (US) 2010-10-21 US disclosed
EP-1614531-A2 Titanium-polymer hybrid laminates The Boeing Company (US) 2006-01-11 EP disclosed
EP-0783960-B1 Titanium-polymer hybrid laminates BOEING CO (US) 2005-11-16 EP disclosed
US-6288209-B1 TERMINATION, ENDCAPPING THE UNITED STATES OF AMERICA AS REPRESENTED BY THE ADMINISTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION 2001-09-11 US disclosed
US-6114050-A HYBRID LAMINATE INCLUDES A CENTRAL REINFORCING CORE LAYER HAVING BONDED TO EACH OF ITS SIDES A LAYUP THAT INCLUDES LAYERS OF TITANIUM ALLOY FOIL WITH LAYERS OF A COMPOSITE OF FIBER-FILLED ORGANIC RESIN BETWEEN THE FOIL LAYERS THE BOEING COMPANY (US) 2000-09-05 US disclosed
US-5866272-A AIRCRAFT THE BOEING COMPANY (US) 1999-02-02 US disclosed
EP-0783960-A2 Titanium-polymer hybrid laminates THE BOEING COMPANY (US) 1997-07-16 EP disclosed